Anglo-Spanish War may refer to:
- Hundred Years' War (1337–1453), includes the War of the Breton Succession, the Castilian Civil War, the War of the Two Peters, and the 1383–1385 Portuguese interregnum
- Third Fernandine War (1381–1382)
- War of the League of Cognac (1526–1530), part of the Italian Wars
- Anglo-Spanish War (1585–1604), including the Spanish Armada, the English Armada and the Nine Years' War (Ireland), part of the Eighty Years' War
- Dutch–Portuguese War (1601–1661), part of the Eighty Years' War
- Palatinate campaign (1620–1623), part of the Thirty Years' War
- Anglo-Spanish War (1625–1630), part of the Thirty Years' War (Eighty Years' War, 1621–1648)
- Anglo-Spanish War (1654–1660), part of the Franco-Spanish War
- Portuguese Restoration War (1662–1668), English support for Portugal
- War of the Spanish Succession (1701–1713), British support to Archduke Charles
- War of the Quadruple Alliance (1718–1720)
- Anglo-Spanish War (1727–1729)
- War of Jenkins' Ear (1739–1748), later merged into the War of the Austrian Succession
- Anglo-Spanish War (1762–1763), part of the Seven Years' War
- Anglo-Spanish War (1779–1783), linked to the American Revolutionary War
- Anglo-Spanish War (1796–1808), part of the French Revolutionary and Napoleonic Wars
- The Spanish American wars of independence (1815–1819), British supporting role to the decolonization of the Americas
- First Carlist War (1833–1840), British support to Queen Isabella II against Carlists