Abdu'l-Aziz Khan may refer to:
- Abdu'l-Aziz (1614–1683), ruler of the Khanate of Bukhara (1645–1680)
- Abdulaziz (1830–1876), Ottoman sultan
- Abdul Aziz Khan (cricketer) (fl. 1912–1926)
- Abdul Aziz Khan (Mughal governor), Mughal governor of Shivner
- Abdul Aziz Khan Kaka, Pashtun Nationalist representing freedom fighters against the British Raj