3-Methyl-GABA, also known as HMS3266K11, is an anticonvulsant alkaloid.

Pharmacology

3-Methyl-GABA is an activator of GABA-T, an enzyme that transforms GABA to succinate semialdehyde and glutamate.

It also activates glutamate decarboxylase, an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.[1]

References

  1. ^ Silverman RB, Andruszkiewicz R, Nanavati SM, Taylor CP, Vartanian MG (July 1991). "3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase". Journal of Medicinal Chemistry. 34 (7): 2295–2298. doi:10.1021/jm00111a053. PMID 2067001.
Allikas: https://en.wikipedia.org/wiki/3-Methyl-GABA
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