The 2010 Humboldt State Lumberjacks football team represented Humboldt State University—now known as California State Polytechnic University, Humboldt—as a member of the Great Northwest Athletic Conference (GNAC) during the 2010 NCAA Division II football season. Led by third-year head coach Rob Smith, the Lumberjacks compiled an overall record of 8–3 with a mark of 6–2 in conference play, placing second in the GNAC. The team averaged over 30 points per game, outscoring opponents 357 to 202 for the season. Humboldt State played home games at the Redwood Bowl in Arcata, California.

Date	Opponent	Site	Result	Attendance
September 4	at No. 25 (FCS) Cal Poly*	Alex G. Spanos Stadium San Luis Obispo, CA	L 17–23	7,345
September 11	at Dixie State	Hansen Stadium St. George, UT	W 49–14	3,510
September 18	Menlo*	Redwood Bowl Arcata, CA	W 32–13	3,010
September 25	at Western Oregon	McArthur Field Monmouth, OR	W 14–7	2,762
October 2	No. 21 Central Washington	Redwood Bowl Arcata, CA	W 25–24	4,612
October 9	at Azusa Pacific*	Cougar Athletic Stadium Azusa, CA	W 39–32	5,132
October 16	Dixie State	Redwood Bowl Arcata, CA	W 28–3	5,621
October 23	at Central Washington	Tomlinson Stadium Ellensburg, WA	L 18–26	4,517
October 30	at Simon Fraser	Terry Fox Field Burnaby, BC	W 35–14	923
November 6	Western Oregon	Redwood Bowl Arcata, CA	L 24–26	3,089
November 13	Simon Fraser	Redwood Bowl Arcata, CA	W 66–20	2,621
*Non-conference game Homecoming Rankings from AFCA Poll released prior to the game

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No Humboldt State players were selected in the 2011 NFL draft.^[3][4][5] The following finished their college career in 2010, were not drafted, but played in the NFL.