The 1959 Mitropa Cup was the 19th season of the Mitropa football club tournament. It was won by Honvéd who beat MTK in the two-legged final 6–5 on aggregate.
Quarter-finals
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
Wiener 
|
2–8 |  Honvéd
|
2–1 | 0–7 |
| MTK
|
7–4 |  Dynamo Prague
|
5–0 | 2–4 |
Vojvodina 
|
4–3 | First Vienna
|
1–0 | 3–3 |
| Baník Ostrava
|
3–4 | Partizan
|
1–1 | 2–3 |
Semi-finals
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| MTK
|
2–1 | Vojvodina
|
2–1 | 0–0 |
| Partizan
|
5–5 | Honvéd
|
3–3 | 2–2 |
Finals
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Honvéd
|
6–5 | MTK
|
4–3 | 2–2 |
| 1959 Mitropa Cup Champions |
|---|
 Honvéd 1st Title |