In enzymology, a salutaridine reductase (NADPH) (EC 1.1.1.248) is an enzyme that catalyzes the chemical reaction

salutaridinol + NADP⁺ salutaridine + NADPH + H⁺

Thus, the two substrates of this enzyme are salutaridinol and NADP⁺, whereas its 3 products are salutaridine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is salutaridinol:NADP⁺ 7-oxidoreductase. This enzyme participates in alkaloid biosynthesis i.

• Gerady R, Zenk MH (1993). "Purification and characterization of salutaridine:NADPH 7-oxidoreductase from Papaver somniferum". Phytochemistry. 34 (1): 125–132. doi:10.1016/S0031-9422(00)90793-3.