Rociverine is an antispasmodic drug used to treat urinary, gastrointestinal and biliary spasms.[1] It is antimuscarinic drug.[2]

Medical uses

In India, rociverine is used as part of the "Programmed Labour Protocol" to help reduce pain and shorten the duration of labor. However, an analysis of clinical trials provides little evidence supporting its effectiveness in reducing labor duration.[3]

Pharmacology

The (1R,2R) stereoisomer showed 240-fold greater affinity for the muscarinic receptor, but the (1S,2S) compound showed the best selectivity. [4]

References

  1. ^ "Rociverine".
  2. ^ Toson G, Schiantarelli P, Murmann W (1978). "Rociverine, a new antispasmodic agent with balanced neurotropic and myotropic activity". Arzneimittel-Forschung. 28 (7): 1130–42. PMID 582702.
  3. ^ Rohwer AC, Khondowe O, Young T (June 2013). "Antispasmodics for labour". The Cochrane Database of Systematic Reviews. 2013 (6): CD009243. doi:10.1002/14651858.CD009243.pub3. PMC 6823273. PMID 23737030.
  4. ^ Barbier P, Renzetti AR, Turbanti L, Di Bugno C, Fornai F, Vaglini F, et al. (July 1995). "Stereoselective inhibition of muscarinic receptor subtypes by the eight stereoisomers related to rociverine". European Journal of Pharmacology. 290 (2): 125–132. doi:10.1016/0922-4106(95)90024-1. PMID 8575526.


Allikas: https://en.wikipedia.org/wiki/Rociverine
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