The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.[1][2]
Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.
| receptor/gene | ligands | activates | inhibits |
|---|---|---|---|
| RXFP1 | relaxin 1, relaxin 2, relaxin 3 | adenylate cyclase, protein kinase A, protein kinase C,
phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2) |
|
| RXFP2 | relaxin 1, relaxin 2, insulin-like 3 | adenylate cyclase | |
| RXFP3 | relaxin 3 | Erk1/2 signaling | adenylate cyclase |
| RXFP4 | relaxin 3, insulin-like 3 | adenylate cyclase |
See also
- Relaxin family peptide hormones
- Insulin/IGF/Relaxin family
- Relaxin/insulin-like family peptide receptor 1
References
- ^ Bathgate RA, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides". Pharmacol. Rev. 58 (1): 7–31. doi:10.1124/pr.58.1.9. PMID 16507880. S2CID 7466039.
- ^ Halls ML, van der Westhuizen ET, Bathgate RA, Summers RJ (2007). "Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways". Br. J. Pharmacol. 150 (6): 677–91. doi:10.1038/sj.bjp.0707140. PMC 2013861. PMID 17293890.
External links
- "Relaxin Family Peptide Receptors: Motilin". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
- relaxin+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)