Plastique is an obsolete term for plastic explosive.
Plastique may also refer to:
- Plastique (character), DC comic book character
- Plastique (Arrowverse), a version of the character in the Arrowverse
- "Plastique" (The Flash episode), an episode of The Flash
- "Plastique" (Smallville), an episode of Smallville centered on another version of the character
- Plastique Tiara, Vietnamese-American drag queen