Retinal isomerase (EC 5.2.1.3) is an enzyme that catalyzes the isomerisation of all-trans-retinal in the eye into 11-cis-retinal which is the form that most opsins bind.
- all-trans-retinal 11-cis-retinal
Hence, this enzyme has one substrate, all-trans-retinal, and one product, 11-cis-retinal.
This enzyme belongs to the family of isomerases, specifically cis-trans isomerases. Its systematic name is all-trans-retinal 11-cis-trans-isomerase. Other names are retinene isomerase, and retinoid isomerase. This enzyme participates in the retinol metabolism.
References
- HUBBARD R (1956). "Retinene isomerase". J. Gen. Physiol. 39 (6): 935–62. doi:10.1085/jgp.39.6.935. PMC 2147571. PMID 13346046.
- Shichi H, Somers RL (1974). "Possible involvement of retinylidene phospholipid in photoisomerization of all-trans-retinal to 11-cis-retinal". J. Biol. Chem. 249 (20): 6570–7. PMID 4472816.
