Myclobutanil is a triazole chemical used as a fungicide. It is a steroid demethylation (CYP51) inhibitor, specifically inhibiting ergosterol biosynthesis. Ergosterol is a critical component of fungal cell membranes.
Stereoisomerism
| Myclobutanil (2 stereoisomers) | |
|---|---|
 (S)-configuration |
 (R)-configuration |
Safety
The Safety Data Sheet indicates the following hazards:
- Suspected of damaging fertility or the unborn child.
- Toxic to aquatic life with long lasting effects.[1]
The first hazard has caused this chemical to be placed on the 1986 California Proposition 65 toxics list.
When heated, myclobutanil decomposes to produce corrosive and/or toxic fumes, including carbon monoxide, carbon dioxide, hydrogen chloride, hydrogen cyanide, and nitrogen oxides.[2][3]
Banned for cannabis cultivation
Myclobutanil is banned in Canada, Colorado, Washington, Oregon, and Oklahoma for the production of medical and recreational cannabis. In 2014, a Canadian news investigation by The Globe and Mail reported the discovery of myclobutanil in medical cannabis produced by at least one government licensed grower.[4] In September 2019, NBC News commissioned CannaSafe to test THC cartridges for heavy metals, pesticides, and residual solvents like Vitamin E; pesticides, including myclobutanil, was found in products from unlicensed dealers.[5] In Michigan, the current state action limit for myclobutanil is 200 ppb in cannabis products.[6]
References
- ^ "SAFETY DATA SHEET Myclobutanil" (PDF). Cayman Chemical Company. Retrieved 11 August 2021.
- ^ GOV, NOAA Office of Response and Restoration, US. "MYCLOBUTANIL - CAMEO Chemicals - NOAA". cameochemicals.noaa.gov.
{{cite web}}: CS1 maint: multiple names: authors list (link) - ^ "Product Safety Assessment: Myclobutanil".
- ^ "Canadians not told about banned pesticide found in medical pot supply" – via The Globe and Mail.
- ^ "Tests show bootleg marijuana vapes tainted with hydrogen cyanide". NBC News.
- ^ "Technical Bulletin".
External links
- Myclobutanil in the Pesticide Properties DataBase (PPDB)
- International Programme on Chemical Safety