Don or Donald McKenzie (also Mackenzie or MacKenzie) may refer to:

• Don MacKenzie (rower) (1874–1925), Canadian rower who won a medal at the 1904 Summer Olympics
• Don MacKenzie (footballer), English footballer, winger for Rochdale
• D. K. A. MacKenzie (1916–1940), Scottish rugby union player
• Don McKenzie (Canadian football) (c. 1920–2001), Canadian football player
• Don McKenzie (footballer, born 1927) (1927–1987), Scottish footballer for Grimsby Town
• Don McKenzie (footballer, born 1939), Australian rules footballer with Essendon
• Don McKenzie (footballer, born 1942), Australian rules footballer and coach of Footscray
• Don McKenzie (swimmer) (1947–2008), American Olympic swimmer
• Donnie McKenzie (born 1960), British Olympic fencer
• Donald MacKenzie (archer), American archer
• Don McKenzie (curler) (born 1957), Canadian curler

• Donald McKenzie (explorer) (1753–1851), Scottish-Canadian explorer and governor of the Red River Settlement
• Donald Mackenzie, Lord Mackenzie (1818–1875), Scottish judge, styled Lord Mackenzie
• Donald MacKenzie (Ontario politician), provincial politician from Middlesex East, 1883–1886
• Donald Gordon McKenzie (1887–1963), member of the Legislative Assembly of Manitoba
• Donald Mackenzie-Kennedy (1889–1965), Governor of Nyasaland (1939–1942)

• Donald Alexander Mackenzie (1873–1936), Scottish journalist and writer on mythology
• Donald C. MacKenzie (born c. 1930s), Canadian Forces Air Command general
• Donald McKenzie (academic) (1931–1999), New Zealander bibliographer
• Donald Angus MacKenzie (born 1950), professor of sociology at the University of Edinburgh, Scotland
• Don McKenzie (sports medicine), Canadian founder of Abreast in a Boat

• The Strength of Donald McKenzie, 1916 American silent short film
• McKenzie Lectures, in memory of Donald McKenzie, bibliographer