Coco Gauff and Jessica Pegula defeated Gabriela Dabrowski and Giuliana Olmos in the final, 1–6, 7–5, [10–4] to win the women's doubles tennis title at the 2022 San Diego Open.^[1]

This was the first WTA Tour-level event to be held in the San Diego area since 2013.^[2]

	First round							Quarterfinals							Semifinals							Final
	1	C Gauff J Pegula	7	6
		Y Xu Z Yang	5	0				1	C Gauff J Pegula	6	77
		S Kenin L Samsonova	6	6					S Kenin L Samsonova	2	63
		R Marino C Zhao	2	4											1	C Gauff J Pegula	6	77
	4	D Krawczyk D Schuurs	1	6	[10]										4	D Krawczyk D Schuurs	3	65
		A Danilina A Sasnovich	6	4	[4]			4	D Krawczyk D Schuurs	7	4	[10]
		A Rosolska E Routliffe	6	4	[7]				A Guarachi A Klepač	5	6	[5]
		A Guarachi A Klepač	1	6	[10]																	1	C Gauff J Pegula	1	7	[10]
	WC	A Ahn K Hui	0	4																		2	G Dabrowski G Olmos	6	5	[4]
	PR	S Sanders L Stefani	6	6				PR	S Sanders L Stefani	1	1
		S Aoyama E Hozumi	4	6	[5]			3	N Melichar-Martinez E Perez	6	6
	3	N Melichar-Martinez E Perez	6	3	[10]										3	N Melichar-Martinez E Perez	0	3
		H-c Chan L Hradecká	6	5	[10]										2	G Dabrowski G Olmos	6	6
		L Kichenok K Zimmermann	4	7	[8]				H-c Chan L Hradecká	5	6	[7]
		K Christian S Santamaria	5	1				2	G Dabrowski G Olmos	7	4	[10]
	2	G Dabrowski G Olmos	7	6

• Main draw