The 2022 Charlottesville Men's Pro Challenger was a professional tennis tournament played on indoor hard courts. It was the 13th edition of the tournament which was part of the 2022 ATP Challenger Tour, taking place in Charlottesville, United States from October 31 and November 6, 2022.

Country	Player	Rank1	Seed
USA	Denis Kudla	102	1
USA	Michael Mmoh	111	2
USA	Stefan Kozlov	133	3
USA	Christopher Eubanks	137	4
ARG	Juan Pablo Ficovich	148	5
USA	Ben Shelton	158	6
USA	Aleksandar Kovacevic	165	7
USA	Emilio Nava	173	8

• ¹ Rankings are as of 24 October 2022.^[1]

The following players received wildcards into the singles main draw:

• Alafia Ayeni
• Iñaki Montes de la Torre
• Ethan Quinn

The following player received entry into the singles main draw as a special exempt:

• Tennys Sandgren

The following players received entry into the singles main draw as alternates:

• Aziz Dougaz
• Lucas Gerch

The following players received entry from the qualifying draw:

• Ulises Blanch
• Murphy Cassone
• Edan Leshem
• Aidan McHugh
• Nathan Ponwith
• Chris Rodesch

• Ben Shelton def. Christopher Eubanks 7–6^(7–4), 7–5.

• Julian Cash / Henry Patten def. Alex Lawson / Artem Sitak 6–2, 6–4.