The 2022 Challenger Coquimbo was a professional tennis tournament played on clay courts. It was part of the 2022 ATP Challenger Tour. It took place in Coquimbo, Chile between 9 and 14 May 2022.

Country	Player	Rank1	Seed
CHI	Tomás Barrios Vera	145	1
ARG	Santiago Rodríguez Taverna	201	2
ARG	Andrea Collarini	227	3
ARG	Genaro Alberto Olivieri	241	4
CHI	Gonzalo Lama	259	5
BRA	Daniel Dutra da Silva	284	6
BRA	Orlando Luz	287	7
COL	Nicolás Mejía	291	8

• Rankings are as of 2 May 2022.^[1]

The following players received wildcards into the singles main draw:

• Pedro Boscardin Dias
• Santiago Rodríguez Taverna
• Nicolás Villalón

The following players received entry into the singles main draw as alternates:

• Román Andrés Burruchaga
• Matías Franco Descotte

The following players received entry from the qualifying draw:

• Murkel Dellien
• Arklon Huertas del Pino
• Conner Huertas del Pino
• Wilson Leite
• Naoki Nakagawa
• João Lucas Reis da Silva

• Facundo Díaz Acosta def. Pedro Boscardin Dias 7–5, 7–6^(7–4).

• Guillermo Durán / Nicolás Mejía def. Diego Hidalgo / Cristian Rodríguez 6–4, 1–6, [10–7].