Novak Djokovic defeated Stefanos Tsitsipas in the final, 6–3, 6–4 to win the singles tennis title at the 2022 Astana Open.^[1] It was his 90th ATP Tour-level singles title.

Kwon Soon-woo was the reigning champion,^[2] but chose to compete in Tokyo instead.

	Semifinals							Final
	5	Andrey Rublev	6	4	3
	3	Stefanos Tsitsipas	4	6	6
								3	Stefanos Tsitsipas	3	4
								4/WC	Novak Djokovic	6	6
	4/WC	Novak Djokovic	4	78	0
	2	Daniil Medvedev	6	66	0r

	First round							Second round							Quarterfinals							Semifinals
	1	C Alcaraz	5	3
	LL	D Goffin	7	6				LL	D Goffin	6	1	5
		A Mannarino	1	6	6				A Mannarino	3	6	7
	WC	S Wawrinka	6	2	3											A Mannarino	1	2
	Q	Z Zhang	4	6	6										5	A Rublev	6	6
		A Karatsev	6	4	1			Q	Z Zhang	3	2
	Q	L Djere	4	3				5	A Rublev	6	6
	5	A Rublev	6	6																		5	A Rublev	6	4	3
	3	S Tsitsipas	6	6																		3	S Tsitsipas	4	6	6
	WC	M Kukushkin	3	4				3	S Tsitsipas	77	77
	Q	A Shevchenko	64	2				Q	L Nardi	62	63
	Q	L Nardi	77	6											3	S Tsitsipas	710	6
		T Griekspoor	0	6	3										7	H Hurkacz	68	3
		A Bublik	6	4	6				A Bublik	4	4
		F Cerúndolo	2	62				7	H Hurkacz	6	6
	7	H Hurkacz	6	77

	First round							Second round							Quarterfinals							Semifinals
	9	M Čilić	5	77	6
		O Otte	7	64	2			9	M Čilić	6	3	3
		M Cressy	4	63					K Khachanov	2	6	6
		K Khachanov	6	77												K Khachanov	4	3
		B van de Zandschulp	6	6											4/WC	N Djokovic	6	6
	WC	B Zhukayev	1	1					B van de Zandschulp	3	1
		C Garín	1	1				4/WC	N Djokovic	6	6
	4/WC	N Djokovic	6	6																		4/WC	N Djokovic	4	78	0
	8	F Auger-Aliassime	4	66																		2	D Medvedev	6	66	0r
		R Bautista Agut	6	78					R Bautista Agut	6	77
	LL	P Kotov	6	6				LL	P Kotov	1	65
		A Davidovich Fokina	4	4												R Bautista Agut	1	1
	SE	M-A Hüsler	0	2											2	D Medvedev	6	6
		E Ruusuvuori	6	6					E Ruusuvuori	3	2
		A Ramos Viñolas	3	1				2	D Medvedev	6	6
	2	D Medvedev	6	6

	First round							Qualifying competition
	1	David Goffin	6	6
		Denis Yevseyev	1	4
								1	David Goffin	6	63	62
								7	Luca Nardi	3	77	77
	WC	Hamad Međedović	1	3
	7	Luca Nardi	6	6

	First round							Qualifying competition
	2	Daniel Elahi Galán	7	60	2
	WC	Aleksandr Nedovyesov	5	77	6
								WC	Aleksandr Nedovyesov	65	3
								5	Zhang Zhizhen	77	6
		Cem İlkel	710	2	1
	5	Zhang Zhizhen	68	6	6

	First round							Qualifying competition
	3	Laslo Đere	6	6
		Denis Istomin	1	4
								3	Laslo Đere	6	6
								8	Altuğ Çelikbilek	3	4
		Grigoriy Lomakin	3	3
	8	Altuğ Çelikbilek	6	6

	First round							Qualifying competition
	4	Pavel Kotov	6	6
	WC	Arslanbek Aitkulov	0	0
								4	Pavel Kotov	611	3
								6	Alexander Shevchenko	713	6
	Alt	Yan Bondarevskiy	0	0
	6	Alexander Shevchenko	6	6

• Main draw
• Qualifying draw