USS Pope may refer to the following ships of the United States Navy:
- USS Pope (DD-225), a Clemson-class destroyer, commissioned in 1920 and sunk in battle in 1942.
- USS Pope (DE-134), an Edsall-class destroyer escort, commissioned in 1943 and decommissioned in 1946.
See also
- USS General John Pope (AP-110), a troop transport which saw service during World War II and later as a commercial freighter.
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