U.S. Route 63 (US 63) is a north-south U.S. highway that begins in Ruston, LA. In the US state of Arkansas the highway enters the state from Louisiana concurrent with US 167 in Junction City. The highway runs north through the eastern part of the state, serving rural areas of South Arkansas and the Arkansas Delta, as well as Pine Bluff and Jonesboro. The highway exits the state at Mammoth Spring traveling into Missouri.

U.S. 63 enters into Arkansas from Louisiana concurrent with US 167 in Junction City. Just a few miles into the state, the two highways run on the eastern edge of El Dorado as an expressway. US 167 splits here, traveling towards Hampton. US 63 bypasses the town of Warren, crossing US 270. US 63 passes through the rural Cleveland County, then enters into Jefferson County.

In Jefferson County, US 63 serves the city of Pine Bluff. US 63 bypasses the city, running on the last 3 miles of I-530. Also in Pine Bluff, the highway overlaps with US 65 and US 79. US 63 runs northeast with US 79 until Stuttgart, where the highway runs north to Hazen. Just north of Hazen, US 63 overlaps with I-40 to Brinkley. In Brinkley, US 63 begins an overlap with US 49 north to Jonesboro. US 63 leaves US 49 and follows I-555 until I-555 terminates, together serving as a bypass for southern Jonesboro. In Hoxie, US 63 intersects with I-57/US 67. Northwest of here near Portia the highway overlaps with US 412.

In Imboden, US 62 joins this overlap. In Hardy, US 63 leaves the two highways. In Mammoth Spring, US 63 crosses into Missouri, traveling to West Plains.

Portions of U.S. 63 in northern Arkansas have their origins in the work of the Ozark Trails Association, which established a network of roads in northern Arkansas and southern Missouri beginning in the 1910s. A portion of roadway was mapped out in Arkansas between Mammoth Spring and Memphis, Tennessee, and built c. 1918-22. This roadway was eventually designated Highway A-7, and was later designated U.S. 63. Some of the original infrastructure of this early construction has survived the 1927 Mississippi flood and the realignment of U.S. 63 in 1967. Northwest of Tyronza, Old U.S. 63 runs for about 1-1/4 miles of original concrete pavement;^[1] it was listed on the National Register of Historic Places in 2009.^[2] Four bridges built in the 1920s (three before the 1927 flood and one after, are also on the National Register; three southeast of Marked Tree, and one southeast of Tyronza.^[3][4]

On March 11, 2016, Interstate 555 (I-555) was dedicated after a new resolution passed in December 2015 allowing farm equipment to use the roadway when it became an interstate.

In April 2019, ArDOT submitted an application to AASHTO to reroute US 63 concurrent with US 49 between Brinkley and Jonesboro, eliminating the concurrencies with I-55 and I-555, and part of the concurrency with I-40.^[5] The rerouting took effect in 2021.^[6] However, a small section of US 63 in Jonesboro was redesignated as I-555 on November 23 of the same year, making US 63 partly concurrent with I-555 again.^[7]

County	Location	mi	km	Exit	Destinations	Notes
Union	Junction City	0.0	0.0		US 63 south / US 167 south – Ruston	Continuation into Louisiana
	​	10.4	16.7		AR 7 south – Lockhart, LA	Southern end of AR 7 concurrency
	El Dorado	14.1	22.7		US 82 / AR 15 south – Magnolia, Crossett, South Arkansas Regional Airport	Exit 22 on US 82
		15.0	24.1	15	US 82B / US 167B north (Hillsboro Street)	Interchange
		16.2	26.1	16	US 167 north (AR 7 north) – Fordyce, Camden	Northern end of US 167/AR 7 concurrency
	Old Union	22.5	36.2		AR 129 south (Lawson Road) – Lawson
	​	33.2	53.4		AR 275 south – Strong
Bradley	​	36.4	58.6		AR 600 – Moro Bay State Park
	​	48.9	78.7		AR 160 west – Jersey	Southern end of AR 160 concurrency
	Hermitage	52.7	84.8		US 63B north / AR 160 east – Hermitage, Ingalls	Northern end of AR 160 concurrency
		53.4	85.9		US 63B south – Hermitage
	Carmel	62.2	100.1		AR 8 east – Johnsville	Southern end of AR 8 concurrency
	​	64.1	103.2		AR 980 – Airport
	Warren	65.4	105.3		US 278 – Hampton, Monticello
		65.9	106.1		US 63B north
		66.9	107.7		US 278B
		68.4	110.1		AR 8 west – Fordyce	Northern end of AR 8 concurrency
		69.0	111.0		US 63B south / AR 189 south – Monticello
Cleveland	Rye	74.8	120.4		AR 35 south – Monticello, Lake Monticello	Southern end of AR 35 concurrency
	Pansy				AR 11 north / AR 35 north – Rison, Star City	Northern end of AR 35 concurrency
	Calmer				AR 114 west – Rison	Southern end of AR 114 concurrency
					AR 114 east – Star City	Northern end of AR 114 concurrency
Jefferson	​				AR 54 east – Glendale	Southern end of AR 54 concurrency
	Pinebergen				AR 54 west	Northern end of AR 54 concurrency
	Pine Bluff	107.106	172.370	43	I-530 north (US 65 north / US 79 south) / AR 463 north – Little Rock	Southern end of I-530/US 65/US 79 concurrency
	​			44	AR 530 south – Star City, Monticello	Future I-530 south
	Pine Bluff			46	US 65 south (US 425 south) / AR 190 west (Harding Avenue) – Dumas, McGehee, Lake Village	Northern end of US 65 concurrency; exit number not signed northbound
				I-530 ends, US 65B begins
					US 65B north	Northern end of US 65B concurrency
	​				AR 81 south
	Altheimer				US 79B to US 65 north – Pine Bluff, UAPB
					US 79B south to AR 88 – Reydell, Altheimer Business District
Arkansas	Humphrey				AR 13 north – Humnoke, Carlisle
	​				AR 152 east – Bayou Meto WMA
	​				AR 343 south
	​				US 79B north – De Witt, Phillips Community College
	Stuttgart				US 79 north (West Michigan Street) – Clarendon, Arkansas County Agricultural Museum	Northern end of US 79 concurrency
	​				US 165 – England, Little Rock, De Witt, Clarendon
Prairie	​				AR 980 – Airport
	​				AR 86 west – Slovak	Southern end of AR 86 concurrency
	Siedenstricker				AR 86 east – Tollville	Northern end of AR 86 concurrency
	Hazen				US 70 east – DeValls Bluff, Brinkley	Southern end of US 70 concurrency
					US 70 west – Hazen Business District	Northern end of US 70 concurrency
				193	I-40 west / AR 11 north – Little Rock, Des Arc, Lower White River Museum State Park	Southern end of I-40 concurrency
see I-40, US 49, and I-555
Craighead	Jonesboro			49	AR 91 (Dan Avenue) I-555 ends	Northern end of AR 18 concurrency; northern terminus of I-555
	​				US 63B north – Bono Business District
	​				AR 230 to AR 91 – Alicia, Bono
	​				US 63B south – Bono Business District
Greene	No major junctions
Lawrence	Sedgwick				AR 228 east – Light	Southern end of AR 228 concurrency
					AR 228 west to AR 349	Northern end of AR 228 concurrency
	Walnut Ridge				AR 91 – Egypt
					US 63B north – Hoxie
					I-57 / US 67 / US 412 east – Walnut Ridge, Pocahontas, Paragould, Little Rock	Southern end of US 412 concurrency; exits 121A-B on I-57
	Hoxie				AR 367 – Walnut Ridge, Tuckerman	Interchange; former US 67
	​				US 63B south – Hoxie Business District
	​				US 412B east – Walnut Ridge
	Black Rock				AR 25 – Black Rock, Powhatan, Davidsonville Historic State Park, Powhatan Courthouse, Lake Charles	Interchange
					AR 117 north – Davidsonville Historic State Park	Southern end of AR 117 concurrency
					AR 117 south – Smithville	Northern end of AR 117 concurrency
	Imboden				US 62 east – Pocahontas, Business District	Southern end of US 62 concurrency
					AR 115 south – Smithville, Cave City
Randolph	No major junctions
Lawrence	Ravenden				AR 90 east – Ravenden Springs
Sharp	​				AR 58E west – Williford
	​				AR 58 west – Williford
	Hardy				AR 175 north – Wirth	Southern end of AR 175 concurrency
					US 63B north – Hardy, Historic District
					US 62 west / US 412 west / US 63B south (AR 175 south) to US 167 – Hardy, Ash Flat, Batesville, Mountain Home	Northern end of US 62/US 412/AR 175 concurrency
Fulton	Mammoth Spring				AR 9 south – Salem, Business District
	​				US 63 north – Thayer	Continuation into Missouri
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Route transition

• National Register of Historic Places in Poinsett County, Arkansas

U.S. Route 63
Previous state: Louisiana	Arkansas	Next state: Missouri