Two-time defending champion Rafael Nadal defeated Roger Federer in a rematch of the previous year's final, 6–4, 6–4 to win the singles tennis title at the 2007 Monte Carlo Masters. He did not lose a single set in the entire tournament.

The top eight seeds received a bye into the second round.

	Quarterfinals							Semifinals							Final
	1	Roger Federer	6	6
	12	David Ferrer	4	0
								1	Roger Federer	6	6
								16	Juan Carlos Ferrero	3	4
	16	Juan Carlos Ferrero	5	7	6
	11	Richard Gasquet	7	5	2
															1	Roger Federer	4	4
															2	Rafael Nadal	6	6
	10	Tomáš Berdych	5	6	6
		Robin Söderling	7	3	0
								10	Tomáš Berdych	0	5
								2	Rafael Nadal	6	7
	Q	Philipp Kohlschreiber	2	3
	2	Rafael Nadal	6	6

	First round							Second round							Third round							Quarterfinals
								1	R Federer	77	78
	Q	T Gabashvili	1	3				Q	A Seppi	64	66
	Q	A Seppi	6	6											1	R Federer	6	6
		H-T Lee	78	6												H-T Lee	4	3
		J Björkman	66	1					H-T Lee	6	6
		C Moyà	2	1r				13	M Youzhny	4	3
	13	M Youzhny	6	3																		1	R Federer	6	6
	12	D Ferrer	6	6																		12	D Ferrer	4	0
		G Simon	3	1				12	D Ferrer	6	7
	WC	B Balleret	5	7	2				J Benneteau	1	5
		J Benneteau	7	5	6										12	D Ferrer	7	6
		D Tursunov	7	2	2										6	N Djokovic	5	4
		G Gaudio	5	6	6				G Gaudio	1	6	1
								6	N Djokovic	6	3	6

	First round							Second round							Third round							Quarterfinals
								4	F González	2	6	3
	PR	I Andreev	6	6				PR	I Andreev	6	2	6
		J Acasuso	4	1											PR	I Andreev	3	3
		N Massú	4	7	6										16	J C Ferrero	6	6
		F Volandri	6	5	3				N Massú	2	0
		T Henman	5	2				16	J C Ferrero	6	6
	16	J C Ferrero	7	6																		16	J C Ferrero	5	7	6
	11	R Gasquet	7	612	77																	11	R Gasquet	7	5	2
		F Verdasco	5	714	63			11	R Gasquet	6	6
	Q	A Portas	63	5					D Hrbatý	3	2
		D Hrbatý	77	7											11	R Gasquet	6	65	7
		G Monfils	0	0r											7	I Ljubičić	3	77	5
		R Štěpánek	6	2					R Štěpánek	66	65
								7	I Ljubičić	78	77

	First round							Second round							Third round							Quarterfinals
								5	T Robredo	6	6
		A Clément	6	77					A Clément	3	2
	WC	F Serra	4	65											5	T Robredo	6	3	2
		B Becker	77	6											10	T Berdych	1	6	6
	WC	T Johansson	64	2					B Becker	1	2
		N Almagro	0r					10	T Berdych	6	6
	10	T Berdych	5																			10	T Berdych	5	6	6
	14	M Baghdatis	5	4																			R Söderling	7	3	0
		M Mirnyi	7	6					M Mirnyi	7	6
	Q	S Roitman	3	6	6			Q	S Roitman	5	4
		J Melzer	6	1	4											M Mirnyi	65	2
		O Rochus	4	4												R Söderling	77	6
		R Söderling	6	6					R Söderling	6	66	6
								3	N Davydenko	4	78	3

	First round							Second round							Third round							Quarterfinals
								LL	G García López	6	1	6
		M Gicquel	7	5	7				M Gicquel	4	6	3
		F Mayer	5	7	5										LL	G García López	7	64	64
	Q	P Kohlschreiber	6	5	6										Q	P Kohlschreiber	5	77	77
	Q	A Pavel	2	7	4			Q	P Kohlschreiber	7	4
	Q	F Luzzi	6	2	1			9	D Nalbandian	5	1r
	9	D Nalbandian	3	6	6																	Q	P Kohlschreiber	2	3
	15	J Nieminen	7	3	2																	2	R Nadal	6	6
		M Safin	5	6	6				M Safin	6	68	4
		K Vliegen	7	6					K Vliegen	0	710	6
	WC	PH Mathieu	5	3												K Vliegen	3	1
		J I Chela	7	6											2	R Nadal	6	6
	PR	M Verkerk	5	2					J I Chela	3	1
								2	R Nadal	6	6

• Singles draw
• Singles qualification draw