The 2000 Florida State Seminoles football team represented Florida State University in the 2000 NCAA Division I-A football season. The team was coached by Bobby Bowden and played their home games at Doak Campbell Stadium. The defending national champion Seminoles reached the title game for the third straight year and quarterback Chris Weinke won the school's second Heisman Trophy.

As a senior in 2000, Chris Weinke led the nation in passing with 4,167 yards and won the Heisman Trophy, awarded to college football's best player, as well as the Davey O'Brien Award and the Johnny Unitas Award. He also led the Seminoles to the Orange Bowl for their third title game in as many years, however the team failed to defend their title and lost 13–2 to the Oklahoma Sooners. At the age of 28, Weinke was the oldest player in history to win the Heisman Trophy. He finished his Florida State career with a 32–3 record and held numerous FSU records including most passing yards in a career and most career touchdown passes.

Date	Time	Opponent	Rank	Site	TV	Result	Attendance	Source
August 26	8:00 p.m.	vs. BYU*	No. 2	Alltel Stadium Jacksonville, FL (Pigskin Classic)	ABC	W 29–3	54,260
September 9	8:00 p.m.	at Georgia Tech	No. 2	Bobby Dodd Stadium Atlanta, GA	ABC	W 26–21	46,381
September 16	3:30 p.m.	North Carolina	No. 2	Doak Campbell Stadium Tallahassee, FL	ABC	W 63–14	79,287
September 23	6:00 p.m.	Louisville*	No. 2	Doak Campbell Stadium Tallahassee, FL	ESPN2	W 31–0	80,741
September 28	12:00 p.m.	at Maryland	No. 2	Byrd Stadium College Park, MD	ESPN	W 59–7	47,044
October 7	12:00 p.m.	at No. 7 Miami (FL)*	No. 1	Miami Orange Bowl Miami, FL (rivalry, College GameDay)	CBS	L 24–27	80,905
October 14	7:00 p.m.	Duke	No. 7	Doak Campbell Stadium Tallahassee, FL	PPV	W 63–14	80,280
October 21	3:30 p.m.	Virginia	No. 6	Doak Campbell Stadium Tallahassee, FL (Jefferson-Eppes Trophy)	ABC	W 37–3	79,121
October 28	7:00 p.m.	at No. 21 NC State	No. 6	Carter–Finley Stadium Raleigh, NC	ESPN	W 58–14	52,384
November 4	7:30 p.m.	No. 10 Clemson	No. 4	Doak Campbell Stadium Tallahassee, FL (rivalry)	ESPN	W 54–7	82,514
November 11	8:00 p.m.	at Wake Forest	No. 3	Groves Stadium Winston-Salem, NC	PPV	W 35–6	27,071
November 18	8:00 p.m.	No. 4 Florida*	No. 3	Doak Campbell Stadium Tallahassee, FL (rivalry, College GameDay)	ABC	W 30–7	83,042	[1]
January 3	8:00 p.m.	vs. No. 1 Oklahoma*	No. 3	Pro Player Stadium Miami Gardens, FL (Orange Bowl, College GameDay)	ABC	L 2–13	76,835
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Eastern time

• Chris Weinke, Heisman Trophy^[2]
• Chris Weinke, Sammy Baugh Trophy^[3]
• Chris Weinke, Davey O'Brien Award
• Chris Weinke, Johnny Unitas Golden Arm Award
• Jamal Reynolds, Defensive End, Lombardi Award^[4]

^[5]