Frank Parker defeated Bill Talbert 14–12, 6–1, 6–2 in the final to win the men's singles tennis title at the 1945 U.S. National Championships.^[2]

The seeded players are listed below. Frank Parker is the champion; others show the round in which they were eliminated.

• Q = Qualifier
• WC = Wild card
• LL = Lucky loser
• r = Retired

	Quarterfinals									Semifinals									Final
	1	Frank Parker	6	6	6
	7	Seymour Greenberg	2	3	2
										1	Frank Parker	6	8	7
										6	Elwood Cooke	1	6	5
		Sidney Wood	12	5	4	6	0
	6	Elwood Cooke	10	7	6	2	6
																			1	Frank Parker	14	6	6
																			2	Bill Talbert	12	1	2
	2	Bill Talbert	6	6	9
	(3)	Alejo Russell	1	2	7
										2	Bill Talbert	7	6	6
										3	Pancho Segura	5	3	4
	3	Pancho Segura	6	4	6	6
	8	Robert Falkenburg	2	6	1	1

	First round									Second round									Third round									Quarterfinals
										1	Parker	6	6
											Ball	1	2
																			1	Parker	6	6
																				Ray	1	0
											Ray	6	6
										(5)	Guerrero-Arcocha	4	2
																												1	Parker	6	6	6
																												7	Greenberg	2	3	2
										7	Greenberg	6	6
											Chambers	1	3
																			7	Greenberg	6	6
																				Molloy	1	1
											Molloy
										(4)	Hecht	w/o

	First round									Second round									Third round									Quarterfinals
	4	Mulloy	6	6
		Schwartz	4	4						4	Mulloy	6	3	4
		Guernsey	8	6							Guernsey	4	6	6
		Rowbotham	6	4																Guernsey	3	2
		Buzolich	6	6																Wood	6	6
		McManus	4	4							Buzolich	3	3
		Wood	6	8							Wood	6	6
	(6)	Rochon	3	6																									Wood	12	5	4	6	0
	6	Cooke	6	6																								6	Cooke	10	7	6	2	6
		Bartzen	1	4						6	Cooke	6	5	6
		Hall	6	6							Hall	3	7	2
		Steele Jr.	4	1															6	Cooke	6	6
		Brown	6	6	6															Flam	2	2
		Burke	8	4	1						Brown	5	2
		Flam	6	6							Flam	7	6
	(2)	Weiss	1	2

	First round									Second round									Third round									Quarterfinals
	2	Talbert	6	6
		Hunt	1	0						2	Talbert	6	6
		Dixon	6	4	6						Dixon	3	2
		Bender	2	6	4														2	Talbert	6	6
		Behrens	6	6																Behrens	1	4
		West	0	3							Behrens	3	6	6
	(7)	Macken	6	7						(7)	Macken	6	3	3
		Van Ryn	3	5																								2	Talbert	6	6	9
	5	Shields	6	6																								(3)	Russell	1	2	7
		Hamilton	3	2						5	Shields	6	6
		Moylan	8	6							Moylan	3	2
		Giles	6	2															5	Shields	6	4	2
		Peacock	6	6															(3)	Russell	4	6	6
		Osten	0	3							Peacock	2	3
	(3)	Russell	7	6						(3)	Russell	6	6
		Tuero	5	2

	First round									Second round									Third round									Quarterfinals
										3	Segura	6	6
											Buttimer	2	4
																			3	Segura	7	6	6
																				Surface	5	8	2
											Surface	6	3	6
											Thomas	4	6	3
																												3	Segura	6	4	6	6
																												8	Falkenburg	2	6	1	1
										8	Falkenburg	6	6
											Henderson	2	2
																			8	Falkenburg	7	6
																				Livingstone	5	4
											Livingstone	6	1	6
										(1)	Hammersley	3	6	3

• 1945 U.S. National Championships on ITFtennis.com Archived 2020-01-09 at the Wayback Machine, the source for this draw