1-Naphthoic acid is an organic compound with the formula C10H7CO2H. It is one of two isomeric monocarboxylic acids of naphthalene, the other one being 2-naphthoic acid. In general the hydroxynaphthoic acids are more widely used than the parent naphthoic acids.
Synthesis and reactions
1-Naphthoic acid can be prepared by carboxylation of the Grignard reagent generated from 1-bromonaphthalene.[1]
1-Naphthoic acid is a substrate for C-H activation reactions.[2] I
See also
- Hydroxynaphthoic acids
- Classes of synthetic cannabinoids
- Naphthoylindoles, or 3-(1-naphthoyl)indoles
- Naphthoylpyrroles, or 3-(1-naphthoyl)pyrroles
- Natural products containing 1-naphthoic acid moiety
- Neocarzinostatin (as 2-hydroxy-7-methoxy-5-methyl-1-naphthoate)
- Azinomycin B (as 3-methoxy-5-methyl-1-naphthoate)
References
- ^ Gilman, Henry; St. John, Nina B.; Schulze., F. (1931). "α-Naphthoic Acid". Organic Syntheses. 11: 80. doi:10.15227/orgsyn.011.0080.
- ^ Mochida, Satoshi; Hirano, Koji; Satoh, Tetsuya; Miura, Masahiro (2011). "Rhodium-Catalyzed Regioselective Olefination Directed by a Carboxylic Group". The Journal of Organic Chemistry. 76 (9): 3024–3033. doi:10.1021/jo200509m. PMID 21438629.
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