San Luis (Spanish for "Saint Louis") may refer to:

• San Luis Province
• San Luis, Argentina, capital of San Luis Province

• San Luis, Belize, in Orange Walk District

• San Luis, Antioquia, a town and municipality in the Antioquia Department
• San Luis de Palenque, a town and municipality in the Casanare Department
• San Luis, Tolima, a town and municipality in the Tolima Department

• San Luis District, Turrubares, San José province

• San Luis, Pinar del Río
• San Luis, Santiago de Cuba

• Fortaleza San Luis, a Spanish colonial fort in Santiago
• San Luis, Santo Domingo, a town and municipality in the Santo Domingo Province

• San Luis, El Petén

• San Luis, Santa Bárbara

• San Luis, Baja California
• San Luis Acatlán, Guerrero
• San Luis de la Paz, Guanajuato
• San Luis Potosí, a state
• San Luis Potosí, San Luis Potosí, that state's capital city
• San Luis Río Colorado, Sonora
• San Luis Soyatlán, Jalisco
• Sierra San Luis, a mountain range in Chihuahua-Sonora

• San Luis, Ancash, capital of Carlos Fermín Fitzcarrald Province in Ancash Region
• San Luis District, Cañete, Lima Region
• San Luis District, Carlos Fermín Fitzcarrald
• San Luis District, Lima
• San Luis District, San Pablo

• San Luis, Agusan del Sur
• San Luis, Aurora
• San Luis, Batangas
• San Luis, Pampanga

• San Luis, the Spanish name for Sant Lluís, a municipality on Menorca, Spain

• San Luis, Arizona
• San Luis, Colorado
• San Luis Mountains in Arizona
• San Luis Obispo, California
• San Luis Reservoir in California
• San Luis Valley in Colorado
• Mission San Luis Rey de Francia in California
• Mission San Luis de Apalachee in Florida

• San Luis, Uruguay, in Canelones Department
• San Luis al Medio, Rocha
• San Luis River, Rocha

• San Luis, Falcón, in the state of Falcón

• San Luis Airport (disambiguation)
• San Luis F.C., a Mexican football (soccer) team
• San Luis de Quillota, a Chilean football team
• ARA San Luis, various ships of the Argentine Navy

• Saint Louis (disambiguation)
• São Luís (disambiguation)