A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes.
H1 agonists promote wakefulness.[1]
H2: Betazole and Impromidine are examples of agonists used in diagnostics to increase histamine.
H3: Betahistine is a weak Histamine1 agonist and a very strong antagonist of the Histamine3 autoreceptor. Antagonizing H3 increases histaminergic tone.
See also
References
- ^ Sakai, N.; Nishino, S. (2013). "Wake-Promoting Medications". Encyclopedia of Sleep. Elsevier. p. 627–633. doi:10.1016/b978-0-12-378610-4.00126-1. ISBN 978-0-12-378611-1.
Although centrally injected histamine or histaminergic H1 agonists promote wakefulness, the systemic administration of these compounds induces various unacceptable side effects via peripheral H1 receptor stimulation.
External links
- Histamine+agonist at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- MeSH list of agents 82017442