Katarina Srebotnik and Nenad Zimonjić defeated Yaroslava Shvedova and Julian Knowle in the final, 4–6, 7–6^(7–5), [11–9] to win the mixed doubles tennis title at the 2010 French Open.

Liezel Huber and Bob Bryan were the reigning champions, but Bryan chose to not compete this year in mixed doubles. Huber partnered Mahesh Bhupathi, but they lost in the first round to Chan Yung-jan and Eric Butorac.

	Semifinals							Final
	6	Katarina Srebotnik Nenad Zimonjić	4	6	[11]
	3	Nuria Llagostera Vives Oliver Marach	6	3	[9]
								6	Katarina Srebotnik Nenad Zimonjić	4	77	[11]
									Yaroslava Shvedova Julian Knowle	6	65	[9]
		Vania King Christopher Kas	4	4
		Yaroslava Shvedova Julian Knowle	6	6

	First round							Second round							Quarterfinals							Semifinals
	1	L Huber M Bhupathi	1	4
		Y-j Chan E Butorac	6	6					Y-j Chan E Butorac	67	7	[8]
	WC	K Mladenovic A Sidorenko	2	3				WC	A Védy M Llodra	79	5	[10]
	WC	A Védy M Llodra	6	6											WC	A Védy M Llodra	77	3	[3]
		E Vesnina A Ram	6	6											6	K Srebotnik N Zimonjić	65	6	[10]
	WC	M Johansson S de Chaunac	2	1					E Vesnina A Ram	3	78	[8]
		A Medina Garrigues M López	2	3				6	K Srebotnik N Zimonjić	6	66	[10]
	6	K Srebotnik N Zimonjić	6	6																		6	K Srebotnik N Zimonjić	4	6	[11]
	3	N Llagostera Vives O Marach	6	6																		3	N Llagostera Vives O Marach	6	3	[9]
		V Razzano D Norman	3	3				3	N Llagostera Vives O Marach	5	6	[10]
	WC	S Cohen-Aloro T Ascione	6	2	[11]			WC	S Cohen-Aloro T Ascione	7	2	[8]
		I Benešová L Dlouhý	3	6	[9]										3	N Llagostera Vives O Marach	79	79
	WC	J Coin N Mahut	1	6	[10]										5	A Kleybanova M Mirnyi	67	67
		E Makarova H Tecău	6	1	[5]			WC	J Coin N Mahut	2	3
	Alt	A Pavlyuchenkova R Hutchins	6	3	[8]			5	A Kleybanova M Mirnyi	6	6
	5	A Kleybanova M Mirnyi	3	6	[10]

	First round							Second round							Quarterfinals							Semifinals
	7	L Raymond W Moodie	64	3
		V King C Kas	77	6					V King C Kas	63	6	[10]
	Alt	A Amanmuradova A-u-H Qureshi	6	64	[10]			Alt	A Amanmuradova A-u-H Qureshi	77	3	[7]
	Alt	C-j Chuang F Polášek	2	77	[3]											V King C Kas	6	3	[10]
		A Hlaváčková M Mertiňák	6	5	[10]											T Garbin M Matkowski	4	6	[7]
		M Niculescu M Kohlmann	2	7	[8]				A Hlaváčková M Mertiňák	3	2
		T Garbin M Matkowski	77	6					T Garbin M Matkowski	6	6
	4	B Mattek-Sands M Knowles	64	1																			V King C Kas	4	4
	8	Z Yan M Fyrstenberg	4	4																			Y Shvedova J Knowle	6	6
		Y Shvedova J Knowle	6	6					Y Shvedova J Knowle	6	6
		B Záhlavová-Strýcová F Čermák	6	2	[16]				B Záhlavová-Strýcová F Čermák	3	3
		P Schnyder D Nestor	2	6	[14]											Y Shvedova J Knowle	6	62	[10]
		R Stubbs R Lindstedt	3	6	[4]										2	C Black L Paes	3	77	[7]
		S-w Hsieh B Soares	6	4	[10]				S-w Hsieh B Soares	5	6	[8]
	WC	P Parmentier M Gicquel	3	3				2	C Black L Paes	7	2	[10]
	2	C Black L Paes	6	6

• Main draw
• 2010 French Open – Doubles draws and results at the International Tennis Federation