Lucio is an Italian and Spanish male given name derived from the Latin name Lucius. In Portuguese, the given name is accented Lúcio.
Lucio is also an Italian surname.
Given name
- Lúcio (Lucimar Ferreira da Silva) (born 1978), Brazilian footballer
- Lucio Abis (1926–2014), Italian politician
- Eduardo Lúcio Esteves Pereira (born 1954), Portuguese goalkeeper
- Lucio Amanti (born 1977), Canadian cellist
- Lucio Battisti (1943–1998), Italian singer-songwriter
- Lucio Blanco (1879–1922), Mexican military officer
- Lucio Cabañas (1938–1974), Mexican teacher, who became a revolutionary
- Lúcio Cardoso (1912–1968), Brazilian writer
- Lúcio Carlos Cajueiro Souza (born 1979), Brazilian footballer
- Lúcio Costa (1902–1998), Brazilian architect and urban planner
- Lucio Dalla (1943–2012), Italian singer-songwriter
- Lúcio Teófilo da Silva (born 1984), Brazilian football player
- Lucio Diodati (born 1955), Italian painter
- Lúcio Idair Frasson (born 1953), Brazilian footballer
- Lúcio Flávio (disambiguation), several people
- Lucio Fontana (1899–1968), Italian painter and sculptor
- Lucio Fulci (1927–1996), Italian horror film director
- Lucio Gutiérrez (born 1957), President of Ecuador from 2003–2005
- Lucio Serrani (born 1961), Italian hammer thrower
- Lúcio Soares (1934–1988), Portuguese footballer
- Lucio Urtubia (1931–2020), Spanish anarchist
- Lucio Tan (born 1934), Filipino businessman
- Lúcio Wagner (born 1976), Bulgarian footballer
Surname
- Francisco Andres Lucio (born 1973), American record producer, singer-songwriter, musician and DJ
- Hanibal Lucić (1485–1553) known in Italian as Annibale Lucio, Croatian language poet and playwright from Venetian Dalmatia
- Johannes Lucius (Croatian: Ivan Lučić, Italian: Giovanni Lucio) (1604–1679), historian
- Lucius Accius (170 – c. 86 BC), Roman tragic poet
- Melissa Lucio (born 1969), American woman on death row in Texas
- Lucius Annaeus Seneca (c. 4 BC – AD 65), Roman philosopher
- Shannon Lucio (born 1980), American actress
Fictional characters
- Lúcio (Overwatch), a player character in the video games Overwatch and Heroes of the Storm
- Lucio, a minor character in Shakespeare's Measure for Measure
- Lucio Marcano, an unseen deceased character in the game Mafia III who appears on a collectible cigarette cards in Mafia: Definitive Edition