Route 5, or Highway 5, may refer to routes in the following countries:

• AH5 Asian Highway 5
• E05 European route E05
• E005 European route E005

• National Route 5

• M5 Motorway (Sydney)
• The Detour or Toll free Route of the M5 East (https://roadsaustralia.weebly.com/sydneys-guide-to-toll-roads.html)

• Tanami Road

• Centenary Motorway (Brisbane)
• 
  • Centenary Motorway (Brisbane)
  • Western Freeway (Brisbane)
• Legacy Way (Brisbane)
• State Route 5 (Queensland) – Peak Downs Highway
• Metroad 5 – Brisbane

• Anzac Highway, Adelaide

• Lake Highway, Tasmania

Metropolitan route 5

• State Route 5 (Western Australia) – Stirling Highway, Mounts Bay Road, Riverside Drive, and The Causeway

• Nord Autobahn

• M 5 M5 highway (Belarus)

• National Route 5 (Bolivia)

• Автомагистрала „Черно море“/Black Sea motorway
• Републикански път I-5/Route 5 (I-5/E85)

• National Highway 5 (Burma)

• National Highway 5 (Cambodia)

• Chile Highway 5 - Panamericana

• Alberta Highway 5
• British Columbia Highway 5 (Yellowhead Highway)
• Manitoba Highway 5
• Northwest Territories Highway 5
• Nova Scotia Trunk 5
• Ontario Highway 5
• Prince Edward Island Route 5
• Quebec Autoroute 5
• Quebec Route 5 (former)
• Saskatchewan Highway 5
• Yukon Highway 5 (Dempster Highway)

• G5 Expressway

• National Route 5

• D5 Motorway

• RN-5 (Djibouti)

• DR-5

• Finnish national road 5 (Vt5)

• Bundesautobahn 5 (A5)
• Bundesstraße 5 (B5)

• A5 motorway (Ionia Odos)
• EO5 road

• CA-5 (Honduras)

• Route 5 (Hong Kong)

• M5 motorway (Hungary)
• Main road 5 (Hungary)

• SH 5
• NH 5

• Indonesian National Route 5

• Freeway 5 (Iran)

• Highway 5 (Iraq)

• N5 road (Ireland)

• Highway 5 (Israel)

• Autostrada A5
• RA 5

• National Route 5
• Dō-Ō Expressway
• Bayshore Route (Port of Osaka-Kobe)
• Route 5 (Nagoya Expressway)

• Highway 5

• National Route 5

• FT 5 Malaysia Federal Route 5
• Shah Alam Expressway Shah Alam Expressway (E5)

• State Highway 5 (New Zealand)

• A5 highway (Nigeria)

• National Route 5

• C-5 Circumferential Road 5
• R-5 Radial Road 5
• N5 highway (Philippines)
• E5 expressway (Philippines)

• National Highway 5 (Republic of the Congo)

• Drumul Naţional 5

• M5 highway (Russia)

• M5 Motorway (Syria)

• National Freeway 5
• Provincial Highway 5 (Taiwan)

• Highway M05 (Ukraine)

• M5 motorway (Great Britain)
• A5 road (Great Britain)
• A5 road (Isle of Man)
• M5 motorway (Northern Ireland)
• A5 road (Northern Ireland)

• Interstate 5
  • Interstate 5W (former)
  • Interstate 5E (former)
• U.S. Route 5
• New England Interstate Route 5 (former)
• Alabama State Route 5
• Alaska Route 5
• Arkansas Highway 5
• California State Route 5 (former)
• Colorado State Highway 5
• Delaware Route 5
• Florida State Road 5
• Georgia State Route 5
• Idaho State Highway 5
• Illinois Route 5
• Indiana State Road 5
• Iowa Highway 5
• K-5 (Kansas highway)
• Kentucky Route 5
• Louisiana Highway 5
• Maine State Route 5
• Maryland Route 5
• M-5 (Michigan highway)
• Minnesota State Highway 5
  • County Road 5 (Dakota County, Minnesota)
  • County Road 5 (Goodhue County, Minnesota)
  • County Road 5 (Hennepin County, Minnesota)
  • County Road 5 (Washington County, Minnesota)
• Mississippi Highway 5
• Missouri Route 5
• Montana Highway 5
• Nebraska Highway 5
• Nevada State Route 5 (former)
  • Nevada State Route 5C (former)
• New Jersey Route 5
  • New Jersey Route 5N (former)
  • County Route 5 (Monmouth County, New Jersey)
• New York State Route 5
  • County Route 5 (Allegany County, New York)
  • County Route 5 (Broome County, New York)
  • County Route 5 (Cattaraugus County, New York)
  • County Route 5 (Chemung County, New York)
  • County Route 5 (Chenango County, New York)
  • County Route 5 (Clinton County, New York)
  • County Route 5 (Dutchess County, New York)
  • County Route 5 (Franklin County, New York)
  • County Route 5 (Jefferson County, New York)
  • County Route 5 (Niagara County, New York)
  • County Route 5 (Oneida County, New York)
  • County Route 5 (Ontario County, New York)
  • County Route 5 (Otsego County, New York)
  • County Route 5 (Rensselaer County, New York)
  • County Route 5 (Rockland County, New York)
  • County Route 5 (Schoharie County, New York)
  • County Route 5 (Steuben County, New York)
  • County Route 5 (Suffolk County, New York)
  • County Route 5 (Tioga County, New York)
  • County Route 5 (Ulster County, New York)
  • County Route 5 (Westchester County, New York)
  • County Route 5 (Wyoming County, New York)
• North Carolina Highway 5
• North Dakota Highway 5
• Ohio State Route 5
• Oklahoma State Highway 5
  • Oklahoma State Highway 5C
• Pennsylvania Route 5
• Rhode Island Route 5
• South Carolina Highway 5
• Tennessee State Route 5
• Texas State Highway 5
  • Texas State Highway Loop 5
  • Texas State Highway Spur 5
  • Texas Farm to Market Road
  • Texas Park Road 5
  • Texas Recreational Road 5 (former)
• Either of two prior designations for highways in Utah
  • Utah State Route 5 (1962-1977), the former state designation for Interstate 215
  • Utah State Route 5 (1910-1962), a former state highway in Weber and Summit counties that, for a time, also included parts of Interstate 80N (Interstate 84)
• Vermont Route F-5
• Virginia State Route 5
• West Virginia Route 5

Territories

• American Samoa Highway 005
• Guam Highway 5
• Puerto Rico Highway 5

• Route 5 Gral. Fructuoso Rivera

• T5 road (Zambia)
• M5 road (Zambia)

• List of A5 roads
• List of N5 roads
• List of highways numbered 5A
• List of highways numbered 5B

Preceded by 4

Lists of highways 5

Succeeded by 6