Combretastatin B-1 is a combretastatin and a dihydrostilbenoid. It can be found in Combretum afrum, the Eastern Cape South African bushwillow tree[1] or in Combretum kraussii, the forest bushwillow.[2]

It can be produced by selective hydrogenation of combretastatin A-1.[1]

It is a potent inhibitor of microtubule assembly in vitro.[1]

References

  1. ^ a b c Pettit, G. R.; Singh, S. B.; Niven, M. L.; Hamel, E.; Schmidt, J. M. (1987). "Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum". Journal of Natural Products. 50 (1): 119–131. doi:10.1021/np50049a016. PMID 3598594.
  2. ^ Bridget K Brookes, Olga V Doudoukina, Lynn C Katsoulis and Joy H D Veale (1999). "Uteroactive constituents from Combretum kraussii". South African Journal of Chemistry. 52 (4): 127. Archived from the original on 8 August 2014.{{cite journal}}: CS1 maint: multiple names: authors list (link)


Allikas: https://en.wikipedia.org/wiki/Combretastatin_B-1
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