Butanilicaine is a local anesthetic. It is also known by the name Hostacaine.

Synthesis

Amide formation by the combination of 2-chloro-6-methylaniline (1) and chloroacetyl chloride (2) gives the intermediate (3), which is used to alkylate N-butylamine (4) to yield butanilicaine.[1][2][3]

References

  1. ^ "Butanilicaine". Thieme. Retrieved 2024-07-01.
  2. ^ Epstein, Elias; Kaminsky, Daniel (1958). "N-(Substituted Aminoacyl)-chloroanilines". Journal of the American Chemical Society. 80 (8): 1892–1895. doi:10.1021/ja01541a028.
  3. ^ GB 782971  1957 to Hoechst AG.



Allikas: https://en.wikipedia.org/wiki/Butanilicaine
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