Wheel of Fortune may refer to:

• Big Six wheel, a casino game also known as the Wheel of Fortune
• Wheel of Fortune video games, based on the game show franchise

• The Wheel of Fortune (novel), 1984, by the English author Susan Howatch
• The Wheel of Fortune (play), 1795, by British writer Richard Cumberland

• "Wheel of Fortune" (1951 song), originally performed by Johnny Hartman; popularized by Kay Starr
• "Wheel of Fortune" (Ace of Base song)
• "Wheel of Fortune" (Eiko Shimamiya song)
• "Wheels of Fortune" (song), first released in 1976 by the Doobie Brothers
• Wheel of Fortune, an album by Susan Raye
• Wheel of Fortune, an album by Robin Williamson and John Renbourn

• The Wheel of Fortune (Burne-Jones), an 1883 painting

• Wheel of Fortune (American game show) (1975–present), created by Merv Griffin
  • International versions:
    • Wheel of Fortune (Australian game show)
    • Wheel of Fortune (British game show)
    • Wheel of Fortune (New Zealand game show)
    • Wheel of Fortune (Philippine game show)
    • La Ruota Della Fortuna, Italian game show
• Wheel of Fortune (1952 game show), airing on CBS, unrelated to the 1975 show

• "Wheel of Fortune", a season 4 episode of The A-Team
• "The Wheel of Fortune", an episode of the 1965 Doctor Who serial The Crusade
• "Wheel of Fortune", an episode of The Dead Zone
• "Wheels of Fortune", a season 9 episode of Frasier

• Wheel of Fortune (house), listed on the U.S. National Register of Historic Places in Kent County, Delaware
• Wheel of Fortune, U.S. Virgin Islands, a settlement on the island of Saint Croix

• Rota Fortunae, a symbol in ancient philosophy
• Wheel of Fortune (Tarot card)
• Wheel of Fortune (horse), a British racehorse