O’Higgins may refer to:

• O'Higgins (surname), lists notable people with the surname
• O'Higgins family

• O'Higgins Region, Chile
• O'Higgins, Chile, commune in the Capitán Prat Province, Aysén Region, Chile
• Villa O'Higgins, the capital of the O'Higgins commune
• Base General Bernardo O'Higgins Riquelme, Antarctica
• O'Higgins Park, Santiago, Chile
• O'Higgins Glacier, a glacier in the Southern Patagonian Ice Field
• O'Higgins (Buenos Aires) [es], a locality in Buenos Aires province, Argentina
• Capitán General Bernardo O'Higgins [es], a locality in the province of Córdoba, Argentina
• Departamento O'Higgins [es], Chaco province, Argentina
• Hotel O'Higgins, Viña del Mar, Chile

• O'Higgins F.C., a football club from Rancagua, Chile
• O'Higgins Braden, a defunct football club from Rancagua, Chile, one of the founder members of O'Higgins F.C.

• Chilean ship O'Higgins, several ships operated by the Chilean Navy:
  • Chilean frigate O'Higgins (1816), a Chilean frigate commanded by Thomas Cochrane, Lord Cochrane
  • Chilean corvette O'Higgins (1866)
  • Chilean cruiser O'Higgins (1897)
  • Chilean cruiser O'Higgins (CL-02), ex-USS Brooklyn (CL-40)
  • Chilean submarine O'Higgins (SS-23)

• Instituto O'Higgins de Rancagua, a private Catholic school located in the center of Rancagua, Chile
• Order of Bernardo O'Higgins, an award issued by Chile awarded to non-Chilean citizens
• O'Higgins disease, a name for Argentine hemorrhagic fever, from the Buenos Aires locality
• 2351 O'Higgins, a minor planet