Diego Cabeza de Vaca (died 1625) was a Roman Catholic prelate who served as Bishop of Crotone (1623–1625).^[1]

A native of the diocese of Seville (Hispalis) in Spain, he was a doctor of theology and a Canon of the cathedral Chapter of Tuy (Tudensis) in Spain. He served as Visitor General of the bishop of Segovia. Cabeza de Vaca was a follower of Cardinal Antonio Zapata y Cisneros, who was Viceroy of Naples from 1620 to 1622.^[2]

On 20 November 1623, Diego Cabeza de Vaca was appointed during the papacy of Pope Urban VIII as Bishop of Crotone.^[1] On 4 February 1624, he was consecrated bishop by Giovanni Garzia Mellini, Cardinal-Priest of Santi Quattro Coronati, with Alessandro di Sangro, Archbishop of Benevento, and Agostino Morosini, Titular Archbishop of Damascus, serving as co-consecrators.^[1] He served as Bishop of Crotone until his death in December 1625.^[1]

• Cheney, David M. "Archdiocese of Crotone-Santa Severina". Catholic-Hierarchy.org. Retrieved June 16, 2018. (for Chronology of Bishops) ^{[self-published]}
• Chow, Gabriel. "Archdiocese of Crotone-Santa Severina". GCatholic.org. Retrieved June 16, 2018. (for Chronology of Bishops) ^{[self-published]}