Cytidine diphosphate glucose, often abbreviated CDP-glucose, is a nucleotide-linked sugar consisting of cytidine diphosphate and glucose.[1][2] This nucleotide saccharide participates in the synthesis of deoxy sugars such as paratose and tyvelose.[3]

Metabolism

CDP-glucose is produced from CTP and glucose-1-phosphate by the enzyme glucose-1-phosphate cytidylyltransferase.[3]

CDP-glucose is an important metabolite in certain bacteria, which synthesize O antigens from it.[3] CDP-glucose can also be used as a substrate for glycogenin, along its native substrate, UDP-glucose. The same is true for TDP-glucose.[4]

References

  1. ^ Samuel G, Reeves P (2003). "Biosynthesis of O-antigens: genes and pathways involved in nucleotide sugar precursor synthesis and O-antigen assembly". Carbohydr. Res. 338 (23): 2503–19. doi:10.1016/j.carres.2003.07.009. PMID 14670712.
  2. ^ Xue M. He and Hung-wen Liu (2002). "Formation of unusual sugars: Mechanistic studies and biosynthetic applications". Annu Rev Biochem. 71: 701–754. doi:10.1146/annurev.biochem.71.110601.135339. PMID 12045109.
  3. ^ a b c Koropatkin, Nicole M.; Cleland, W. Wallace; Holden, Hazel M. (March 2005). "Kinetic and Structural Analysis of α-d-Glucose-1-phosphate Cytidylyltransferase from Salmonella typhi". Journal of Biological Chemistry. 280 (11): 10774–10780. doi:10.1074/jbc.m414111200. ISSN 0021-9258. PMID 15634670.
  4. ^ Alonso, Miriam D.; Lagzdins, Erik J.; Lomako, Joseph; Lomako, Wieslawa M.; Whelan, William J. (1995-02-13). "New and specific nucleoside diphosphate glucose substrates for glycogenin". FEBS Letters. 359 (2–3): 110–112. Bibcode:1995FEBSL.359..110A. doi:10.1016/0014-5793(95)00018-5. ISSN 0014-5793. PMID 7867779.
Allikas: https://en.wikipedia.org/wiki/Cytidine_diphosphate_glucose
No tags for this post.