2C-T-27, also known as 4-benzylthio-2,5-dimethoxyphenethylamine, is a serotonin 5-HT2A receptor agonist and serotonergic psychedelic of the phenethylamine and 2C families.[1][2][3][4] It was first synthesized and described by Daniel Trachsel in 2003.[2][3] 2C-T-27 also interacts with the serotonin 5-HT2C receptor.[4] The drug produces the head-twitch response (HTR), a behavioral proxy of psychedelic effects, in rodents.[5] However, the HTR induced by 2C-T-27 is relatively weak.[1] In any case, 2C-T-27 has been reported to produce hallucinogenic effects in humans.[1]

See also

References

  1. ^ a b c Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German). Solothurn: Nachtschatten-Verlag. pp. 789–795. ISBN 978-3-03788-700-4. OCLC 858805226. Retrieved 29 January 2025.
  2. ^ a b Trachsel D (2003). "Synthese von neuen (Phenylalkyl)aminen zur Untersuchung von Struktur–Aktivitätsbeziehungen. Mitteilung 2: 4-Thio-substituierte [2-(2,5-Dimethoxyphenyl)ethyl]amine (=2,5-Dimethoxybenzolethanamine)" [Synthesis of Novel (Phenylalkyl)amines for the Investigation of Structure–Activity Relationships. Part 2). 4-Thio-Substituted [2-(2,5-Dimethoxyphenyl)ethyl]amines (=2,5-Dimethoxybenzeneethanamines)]. Helvetica Chimica Acta. 86 (7): 2610–2619. doi:10.1002/hlca.200390210. ISSN 0018-019X.
  3. ^ a b Meyers-Riggs B (3 April 2011). "Shulgin's Sulfur Symphony". countyourculture. Retrieved 17 February 2025. 2C-T-27 (2,5-dimethoxy-4-benzylthiophenethylamine ) Synthesized by Daniel Trachsel but has not been bioassayed to public knowledge. [...] Trachsel, D. Synthesis of novel (phenylalkyl)amines for the investigation of structure-activity relationships. Part 2. 4-Thio-substituted [2-(2,5-dimethoxyphenyl)ethyl]amines (=2,5-dimethoxybenzeneethanamines). Helv. Chim. Acta, 5 Aug 2003, 86 (7), 2610–2619.
  4. ^ a b Luethi D, Trachsel D, Hoener MC, Liechti ME (May 2018). "Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs)" (PDF). Neuropharmacology. 134 (Pt A): 141–148. doi:10.1016/j.neuropharm.2017.07.012. PMID 28720478.
  5. ^ Halberstadt AL, Luethi D, Hoener MC, Trachsel D, Brandt SD, Liechti ME (January 2023). "Use of the head-twitch response to investigate the structure-activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines". Psychopharmacology. 240 (1): 115–126. doi:10.1007/s00213-022-06279-2. PMC 9816194. PMID 36477925.



Allikas: https://en.wikipedia.org/wiki/2C-T-27
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