Hubert Hurkacz defeated Jannik Sinner in the final, 7–6^(7–4), 6–4 to win the men's singles tennis title at the 2021 Miami Open. It was his first Masters 1000 singles title, and he became the first Pole to win a Masters 1000 singles title.^[1]

Roger Federer was the reigning champion from when the tournament was last held in 2019, but chose not to participate this year.^[2]

As both Novak Djokovic and Rafael Nadal also chose not to participate, this was the first Masters 1000 tournament since the 2004 Paris Masters without at least one member of the Big Three competing.^[3]

All seeds received a bye into the second round.

Click on the seed number of a player to go to their draw section.

	Quarterfinals							Semifinals							Final
	1	Daniil Medvedev	4	2
	7	Roberto Bautista Agut	6	6
								7	Roberto Bautista Agut	7	4	4
								21	Jannik Sinner	5	6	6
	21	Jannik Sinner	77	6
	32	Alexander Bublik	65	4
															21	Jannik Sinner	64	4
															26	Hubert Hurkacz	77	6
		Sebastian Korda	5	67
	4	Andrey Rublev	7	79
								4	Andrey Rublev	3	4
								26	Hubert Hurkacz	6	6
	26	Hubert Hurkacz	2	6	6
	2	Stefanos Tsitsipas	6	3	4

	First round							Second round							Third round							Fourth round
								1	D Medvedev	6	6
		S Querrey	3	4				PR	Y-h Lu	2	2
	PR	Y-h Lu	6	6											1	D Medvedev	77	67	6
		F López	4	64												A Popyrin	63	79	4
		A Popyrin	6	77					A Popyrin	6	6
								30	R Opelka	4	2
																						1	D Medvedev	6	6
																							F Tiafoe	4	3
								19	D Evans	77	3	3
		F Tiafoe	5	6	6				F Tiafoe	65	6	6
		S Travaglia	7	4	2											F Tiafoe	1	7	6
	Q	E Escobedo	6	6											16	D Lajović	6	5	3
	Q	P Lorenzi	3	2				Q	E Escobedo	2	3
								16	D Lajović	6	6

	First round							Second round							Third round							Fourth round
								11	F Auger-Aliassime	6	6
		P-H Herbert	6	6					P-H Herbert	4	4
		P Sousa	1	3											11	F Auger-Aliassime	65	65
		V Pospisil	3	6	3										18	J Isner	77	77
	Q	M McDonald	6	4	6			Q	M McDonald	6	3	5
								18	J Isner	2	6	7
																						18	J Isner	3	6	67
																						7	R Bautista Agut	6	4	79
								31	J-L Struff	6	6
	LL	F Gaio	64	2					R Berankis	3	4
		R Berankis	77	6											31	J-L Struff	6	3	2
		L Harris	6	79											7	R Bautista Agut	4	6	6
	Q	E Nava	4	67					L Harris
								7	R Bautista Agut	w/o

	First round							Second round							Third round							Fourth round
								3	A Zverev	6	3	1
	WC	C Alcaraz	4	6	5				E Ruusuvuori	1	6	6
		E Ruusuvuori	6	2	7											E Ruusuvuori	4	6	7
	Q	A Tabilo	3	1												M Ymer	6	1	5
		M Ymer	6	6					M Ymer	6	4	6
								27	N Basilashvili	3	6	4
																							E Ruusuvuori	3	2
																						21	J Sinner	6	6
								21	J Sinner	6	6
	WC	H Gaston	6	6				WC	H Gaston	2	2
		D Koepfer	1	4											21	J Sinner	4	77	6
		S Johnson	5	2											14	K Khachanov	6	62	4
		Y Hanfmann	7	6					Y Hanfmann	3	2
								14	K Khachanov	6	6

	First round							Second round							Third round							Fourth round
								9	G Dimitrov	5	5
		C Norrie	6	3	7				C Norrie	7	7
		Y Nishioka	1	6	5											C Norrie	4	6	1
		M Giron	77	6											22	T Fritz	6	3	6
		T Paul	65	4					M Giron	2	2
								22	T Fritz	6	6
																						22	T Fritz	77	3	4
																						32	A Bublik	65	6	6
								32	A Bublik	6	6
		J Veselý	3	7	1				L Đere	3	4
		L Đere	6	5	6										32	A Bublik	6	6
		J Duckworth	6	4	6											J Duckworth	4	4
	Q	M Zverev	2	6	4				J Duckworth	6	6
								8	D Goffin	3	1

	First round							Second round							Third round							Fourth round
								5	D Schwartzman	6	6
		S Caruso	3	4					Y Uchiyama	3	3
		Y Uchiyama	6	6											5	D Schwartzman	6	6
		M Kecmanović	7	65	6										25	A Mannarino	1	4
	Q	L Broady	5	77	1				M Kecmanović	3	4
								25	A Mannarino	6	6
																						5	D Schwartzman	3	6	5
																							S Korda	6	4	7
								17	A Karatsev	6	6
	WC	J Draper	5	0r					M Kukushkin	4	3
		M Kukushkin	7	0											17	A Karatsev	3	0
		S Korda	6	6												S Korda	6	6
		R Albot	3	0					S Korda	1	6	6
								10	F Fognini	6	4	2

	First round							Second round							Third round							Fourth round
								13	C Garín	6	5	65
		M Čilić	6	2	6				M Čilić	3	7	77
		F Coria	3	6	4											M Čilić	6	6
	WC	M Mmoh	4	4												L Musetti	3	4
		L Musetti	6	6					L Musetti	6	6
								23	B Paire	3	3
																							M Čilić	4	4
																						4	A Rublev	6	6
								29	M Fucsovics	77	64	6
	Q	S Mochizuki	3	3				Q	T Kokkinakis	63	77	4
	Q	T Kokkinakis	6	6											29	M Fucsovics	2	1
		P Martínez	4	0r											4	A Rublev	6	6
		T Sandgren	6	2					T Sandgren	1	2
								4	A Rublev	6	6

	First round							Second round							Third round							Fourth round
								6	D Shapovalov	65	6	6
		S-w Kwon	64	77	63				I Ivashka	77	4	4
		I Ivashka	77	64	77										6	D Shapovalov	3	66
		J Chardy	6	3	4										26	H Hurkacz	6	78
		D Kudla	3	6	6				D Kudla	65	4
								26	H Hurkacz	77	6
																						26	H Hurkacz	4	6	77
																						12	M Raonic	6	3	64
								20	U Humbert	6	6
		C O'Connell	66	710	5				J Sousa	1	4
		J Sousa	78	68	7										20	U Humbert	4	5
		J Thompson	78	6											12	M Raonic	6	7
		F Delbonis	66	4					J Thompson	2	1
								12	M Raonic	6	6

	First round							Second round							Third round							Fourth round
								15	A de Minaur	6	3	4
		DE Galán	6	6					DE Galán	4	6	6
	Q	T Seyboth Wild	3	4												DE Galán	66	3
	Q	B Fratangelo	6	6											24	L Sonego	78	6
		F Verdasco	4	4				Q	B Fratangelo	4	65
								24	L Sonego	6	77
																						24	L Sonego	2	62
																						2	S Tsitsipas	6	77
								28	K Nishikori	78	5	6
		A Bedene	77	1	6				A Bedene	66	7	4
	Q	T Fabbiano	65	6	3										28	K Nishikori	3	6	1
	PR	K Anderson	66	5											2	S Tsitsipas	6	3	6
	LL	D Džumhur	78	7				LL	D Džumhur	1	4
								2	S Tsitsipas	6	6

	First round							Qualifying competition
	1	Mackenzie McDonald	6	6
		Roberto Cid Subervi	1	1
								1	Mackenzie McDonald	77	6
								19	Ivo Karlović	63	4
		Tatsuma Ito	3	63
	19	Ivo Karlović	6	77

	First round							Qualifying competition
	2	Thiago Seyboth Wild	6	6
	WC	Toby Kodat	3	3
								2	Thiago Seyboth Wild	6	6
									Mitchell Krueger	2	3
		Mitchell Krueger	6	6
	17	Lorenzo Giustino	4	3

	First round							Qualifying competition
	3	Damir Džumhur	78	6
		Ulises Blanch	66	4
								3	Damir Džumhur	6	3	4
								18	Alejandro Tabilo	4	6	6
		Thai-Son Kwiatkowski	3	4
	18	Alejandro Tabilo	6	6

	First round							Qualifying competition
	4	Cedrik-Marcel Stebe	65	3
		Mario Vilella Martínez	77	6
									Mario Vilella Martínez	5	1
									Thanasi Kokkinakis	7	6
		Thanasi Kokkinakis	6	77
	20	Frederico Ferreira Silva	1	63

	First round							Qualifying competition
	5	Henri Laaksonen	62	6	1
		Jenson Brooksby	77	2	6
									Jenson Brooksby	7	2	5
								22	Thomas Fabbiano	5	6	7
		Roberto Quiroz	4	63
	22	Thomas Fabbiano	6	77

	First round							Qualifying competition
	6	Federico Gaio	6	6
		Brayden Schnur	4	1
								6	Federico Gaio	65	7	2
								15	Liam Broady	77	5	6
	WC	Shang Juncheng	6	1	66
	15	Liam Broady	4	6	78

	First round							Qualifying competition
	7	Daniel Altmaier	1r
	WC	Shintaro Mochizuki	4
								WC	Shintaro Mochizuki	6	6
								21	Emilio Gómez	1	2
		Marius Copil	3	4
	21	Emilio Gómez	6	6

	First round							Qualifying competition
	8	Go Soeda	3	4
		Renzo Olivo	6	6
									Renzo Olivo	62	7	4
								WC	Emilio Nava	77	5	6
	WC	Emilio Nava	3	6	6
	24	Mikael Torpegaard	6	3	2

	First round							Qualifying competition
	9	Brandon Nakashima	65	6	6
		Christopher Eubanks	77	4	4
								9	Brandon Nakashima	4	64
									Ernesto Escobedo	6	77
		Ernesto Escobedo	6	6
	13	Maxime Cressy	3	4

	First round							Qualifying competition
	10	Jason Jung	6	3	6
		Nicolas Mahut	4	6	1
								10	Jason Jung	4	4
								14	Paolo Lorenzi	6	6
		João Menezes	6	65	1
	14	Paolo Lorenzi	3	77	6

	First round							Qualifying competition
	11	Bernabé Zapata Miralles	62	2
		Matteo Viola	77	6
									Matteo Viola	77	4	1
								WC	Mischa Zverev	65	6	6
	WC	Mischa Zverev	77	6
	16	Danilo Petrović	63	2

	First round							Qualifying competition
	12	Marc-Andrea Hüsler	6	7
		Facundo Mena	2	5
								12	Marc-Andrea Hüsler	0	1
									Bjorn Fratangelo	6	6
		Bjorn Fratangelo	7	6
	23	Dmitry Popko	5	2

• Main draw
• Qualifying draw