John Peers and Filip Polášek defeated Aslan Karatsev and Andrey Rublev in the final, 6–3, 7–6^(7–5) to win the men's doubles tennis title at the 2021 Indian Wells Masters.^[1]

Nikola Mektić and Horacio Zeballos were the defending champions from when the tournament was last held in 2019,^[2] but chose to compete with different partners. Mektić played alongside Mate Pavić, but lost to Peers and Polášek in the quarterfinals. Zeballos played alongside Marcel Granollers, but lost to Fabio Fognini and Lorenzo Sonego in the first round.

Mektić usurped his doubles partner Pavić for the ATP No. 1 doubles ranking after the event, as the latter dropped points from the 2019 Shanghai Masters.

	Semifinals							Final
	7	John Peers Filip Polášek	6	77
	8	Ivan Dodig Marcelo Melo	4	61
								7	John Peers Filip Polášek	6	77
									Aslan Karatsev Andrey Rublev	3	65
		Aslan Karatsev Andrey Rublev	6	4	[10]
		Tim Pütz Michael Venus	3	6	[5]

	First round							Second round							Quarterfinals							Semifinals
	1	N Mektić M Pavić	6	6
	WC	M McDonald B Nakashima	2	2				1	N Mektić M Pavić	6	6
		R Klaasen B McLachlan	2	6	[9]				M Arévalo M Middelkoop	1	3
		M Arévalo M Middelkoop	6	0	[11]										1	N Mektić M Pavić	2	3
		W Koolhof J-J Rojer	1	77	[10]										7	J Peers F Polášek	6	6
	PR	A Krajicek A Mies	6	64	[5]				W Koolhof J-J Rojer	4	65
		A Behar G Escobar	5	77	[7]			7	J Peers F Polášek	6	77
	7	J Peers F Polášek	7	61	[10]																	7	J Peers F Polášek	6	77
	3	M Granollers H Zeballos	6	3	[8]																	8	I Dodig M Melo	4	61
		F Fognini L Sonego	3	6	[10]				F Fognini L Sonego	w/o
		D Evans N Skupski	3	4				WC	J Isner J Sock
	WC	J Isner J Sock	6	6												F Fognini L Sonego	3	6	[8]
		R Bautista Agut A Davidovich Fokina	6	3	[9]										8	I Dodig M Melo	6	4	[10]
		S Gillé J Vliegen	4	6	[11]				S Gillé J Vliegen	4	6	[5]
		C Garín S González	78	5	[2]			8	I Dodig M Melo	6	4	[10]
	8	I Dodig M Melo	66	7	[10]

	First round							Second round							Quarterfinals							Semifinals
	6	J Murray B Soares	4	4
		J-L Struff A Zverev	6	6					J-L Struff A Zverev	5	3
		R Bopanna D Shapovalov	6	2	[10]				R Bopanna D Shapovalov	7	6
		F Auger-Aliassime H Hurkacz	1	6	[4]											R Bopanna D Shapovalov	4	4
		A Karatsev A Rublev	6	6												A Karatsev A Rublev	6	6
		A de Minaur R Opelka	4	4					A Karatsev A Rublev	6	5	[10]
		S Bolelli M González	2	6	[11]				S Bolelli M González	3	7	[3]
	4	JS Cabal R Farah	6	3	[9]																		A Karatsev A Rublev	6	4	[10]
	5	K Krawietz H Tecău	6	6																			T Pütz M Venus	3	6	[5]
	Alt	F Krajinović D Lajović	2	3				5	K Krawietz H Tecău	79	77
		L Harris D Schwartzman	3	77	[7]			WC	S Johnson S Querrey	67	64
	WC	S Johnson S Querrey	6	62	[10]										5	K Krawietz H Tecău	4	2
		T Pütz M Venus	7	65	[15]											T Pütz M Venus	6	6
		C Alcaraz P Carreño Busta	5	77	[13]				T Pütz M Venus	4	6	[10]
		C Norrie L Saville	6	3	[8]			2	R Ram J Salisbury	6	4	[6]
	2	R Ram J Salisbury	4	6	[10]

• Main Draw