Novak Djokovic defeated Stefanos Tsitsipas in the final, 6–3, 6–4 to win the men's singles tennis title at the 2019 Madrid Open. It was his 33rd Masters 1000 singles title, tying Rafael Nadal's record. Djokovic did not lose a set during the tournament.

Alexander Zverev was the defending champion,^[1] but lost in the quarterfinals to Tsitsipas.

This tournament marked the last professional appearance of 2013 French Open runner-up and former world No. 3 David Ferrer;^[2] he lost in the second round to Zverev. This was Roger Federer's first clay court tournament since the 2016 Italian Open, and marked the three-time champion's last appearance at the Madrid Open.

The top eight seeds received a bye into the second round.

Click on the seed number of a player to go to their draw section.

	Quarterfinals							Semifinals							Final
	1	Novak Djokovic	w/o
	9	Marin Čilić
								1	Novak Djokovic	77	77
								5	Dominic Thiem	62	64
	4	Roger Federer	6	611	4
	5	Dominic Thiem	3	713	6
															1	Novak Djokovic	6	6
															8	Stefanos Tsitsipas	3	4
	8	Stefanos Tsitsipas	7	3	6
	3	Alexander Zverev	5	6	2
								8	Stefanos Tsitsipas	6	2	6
								2	Rafael Nadal	4	6	3
		Stan Wawrinka	1	2
	2	Rafael Nadal	6	6

	First round							Second round							Third round							Quarterfinals
								1	N Djokovic	6	6
	Q	T Fritz	710	77				Q	T Fritz	4	2
		G Dimitrov	68	64											1	N Djokovic	6	77
		J Chardy	6	4	7											J Chardy	1	62
	Q	A Ramos Viñolas	2	6	5				J Chardy	6	6
		D Schwartzman	6	4	6				D Schwartzman	1	2
	16	M Cecchinato	0	6	1																	1	N Djokovic	w/o
	9	M Čilić	6	2	77																	9	M Čilić
	Q	M Kližan	4	6	60			9	M Čilić	4	6	6
		N Kyrgios	64	4					J-L Struff	6	3	4
		J-L Struff	77	6											9	M Čilić	4	6	6
		D Lajović	4	4												L Đere	6	3	2
		L Đere	6	6					L Đere	6	2	7
								7	JM del Potro	3	6	5

	First round							Second round							Third round							Quarterfinals
								4	R Federer	6	6
		R Gasquet	7	77					R Gasquet	2	3
	WC	A Davidovich Fokina	5	65											4	R Federer	6	4	77
		D Goffin	4	5											15	G Monfils	0	6	63
		M Fucsovics	6	7					M Fucsovics	6	4	2
		A Seppi	3	1				15	G Monfils	1	6	6
	15	G Monfils	6	6																		4	R Federer	6	611	4
	10	F Fognini	6	6																		5	D Thiem	3	713	6
		K Edmund	4	3				10	F Fognini	6	6
		J Millman	77	77					J Millman	2	2
		S Johnson	65	65											10	F Fognini	4	5
	Q	R Opelka	77	6											5	D Thiem	6	7
		P Carreño Busta	65	4				Q	R Opelka	77	3	0r
								5	D Thiem	62	6	1

	First round							Second round							Third round							Quarterfinals
								8	S Tsitsipas	6	7
	LL	A Mannarino	7	5	6			LL	A Mannarino	2	5
		J Sousa	5	7	1										8	S Tsitsipas	6	6
		R Albot	2	6	1											F Verdasco	3	4
		F Verdasco	6	3	6				F Verdasco	64	6	7
	WC	J Munar	4	77	3			11	K Khachanov	77	1	5
	11	K Khachanov	6	65	6																	8	S Tsitsipas	7	3	6
	13	B Ćorić	3	5																		3	A Zverev	5	6	2
		L Pouille	6	7					L Pouille	5	1
		A de Minaur	3	4				Q	H Hurkacz	7	6
	Q	H Hurkacz	6	6											Q	H Hurkacz	6	4	4
	WC	D Ferrer	6	4	6										3	A Zverev	3	6	6
		R Bautista Agut	4	6	4			WC	D Ferrer	4	1
								3	A Zverev	6	6

	First round							Second round							Third round							Quarterfinals
								6	K Nishikori	7	7
		G Simon	6	1	64			Q	H Dellien	5	5
	Q	H Dellien	4	6	77										6	K Nishikori	3	63
		S Wawrinka	6	6												S Wawrinka	6	77
	Q	P-H Herbert	2	3					S Wawrinka	6	6
		G Pella	6	1	6				G Pella	3	4
	12	D Medvedev	2	6	3																		S Wawrinka	1	2
	14	N Basilashvili	710	3	4																	2	R Nadal	6	6
		F Tiafoe	68	6	6				F Tiafoe	6	3	6
		P Kohlschreiber	6	77					P Kohlschreiber	4	6	3
		M Kukushkin	2	65												F Tiafoe	3	4
	WC	F Auger-Aliassime	6	79											2	R Nadal	6	6
		D Shapovalov	2	67				WC	F Auger-Aliassime	3	3
								2	R Nadal	6	6

1. Adrian Mannarino

	First round							Qualifying competition
	1	Pierre-Hugues Herbert	6	6
	Alt	Denis Kudla	3	4
								1	Pierre-Hugues Herbert	5	6	77
								11	Robin Haase	7	3	65
		Bernard Tomic	78	2	5
	11	Robin Haase	66	6	7

	First round							Qualifying competition
	2	Benoît Paire	1	1
		Casper Ruud	6	6
									Casper Ruud	6	63	1
									Albert Ramos Viñolas	2	77	6
		Albert Ramos Viñolas	3	6	77
	14	Taro Daniel	6	3	62

	First round							Qualifying competition
	3	Hubert Hurkacz	6	6
	WC	Marcel Granollers	0	2
								3	Hubert Hurkacz	6	6
								WC	Roberto Carballés Baena	4	4
	WC	Roberto Carballés Baena	77	6
	12	Ugo Humbert	61	1

	First round							Qualifying competition
	4	Damir Džumhur	3	6	3
		Guido Andreozzi	6	1	6
									Guido Andreozzi	6	4	2
									Hugo Dellien	3	6	6
		Hugo Dellien	6	6
	10	Leonardo Mayer	2	4

	First round							Qualifying competition
	5	Adrian Mannarino	6	65	7
	WC	Jorge Plans	4	77	5
								5	Adrian Mannarino	3	2
								9	Martin Kližan	6	6
		Ernests Gulbis	4	67
	9	Martin Kližan	6	79

	First round							Qualifying competition
	6	Mackenzie McDonald	1	2
		Juan Ignacio Londero	6	6
									Juan Ignacio Londero	67	7	2
								8	Reilly Opelka	79	5	6
		Mischa Zverev	62	63
	8	Reilly Opelka	77	77

	First round							Qualifying competition
	7	Taylor Fritz	6	6
	WC	Nicola Kuhn	4	3
								7	Taylor Fritz	77	7
									Marius Copil	65	5
		Marius Copil	5	6	77
	13	Nicolás Jarry	7	4	62

• Main Draw
• Qualifying Draw