The 2019 Cleveland Open was a professional tennis tournament played on hard courts. It was the first edition of the tournament which was part of the 2019 ATP Challenger Tour. It took place in Cleveland, United States between January 28 and February 3, 2019.^[1]

Country	Player	Rank1	Seed
TPE	Jason Jung	120	1
SRB	Miomir Kecmanović	125	2
USA	Noah Rubin	140	3
GER	Dominik Köpfer	160	4
BAR	Darian King	171	5
USA	Tim Smyczek	172	6
ECU	Roberto Quiroz	181	7
CAN	Brayden Schnur	196	8
ESA	Marcelo Arévalo	220	9
GER	Dustin Brown	223	10
BRA	Thomaz Bellucci	225	11
USA	Donald Young	231	12
CAN	Filip Peliwo	240	13
USA	Christian Harrison	242	14
USA	Marcos Giron	249	15
DOM	Roberto Cid Subervi	250	16

• ¹ Rankings are as of 14 January 2019.

The following players received wildcards into the singles main draw:

• Felix Corwin
• Michael Redlicki
• Noah Rubin
• Ryan Shane
• J. J. Wolf

The following players received entry into the singles main draw using their ITF World Tennis Ranking:

• Gijs Brouwer
• Matías Franco Descotte
• Tom Jomby
• Louis Wessels

The following players received entry from the qualifying draw:

• Maxime Cressy
• Jared Hiltzik

The following player received entry as a lucky loser:

• Gonzalo Escobar

• Maxime Cressy def. Mikael Torpegaard 6–7^(4–7), 7–6^(8–6), 6–3.

• Romain Arneodo / Andrei Vasilevski def. Robert Galloway / Nathaniel Lammons 6–4, 7–6^(7–4).