Tezozomoctzin (Classical Nahuatl: Tezozomoc [tesoˈsomok]) was a son of Itzcoatl, the fourth Aztec ruler (tlatoani) of Tenochtitlan.

Tezozomoctzin never became ruler himself, but he was married to Atotoztli II, daughter of his cousin Moctezuma I (the fifth ruler)

They had three sons that each would become rulers: Axayacatl, Tizoc, and Ahuitzotl — would become the sixth, seventh and eighth rulers, respectively. A fourth son Huitzilihuitl is listed in the genealogy, but was never ruler and has no listed children.

His daughter Chalchiuhnenetzin married Moquihuix, ruler of Tlatelolco altepetl.

• Lori Boornazian Diel (12 December 2018). The Codex Mexicanus: A Guide to Life in Late Sixteenth-Century New Spain. University of Texas Press. pp. 88–. ISBN 978-1-4773-1675-7.