Holy Sepulchre Cemetery in Southfield, Michigan, is an American cemetery operated by Catholic Funeral and Cemetery Services, a ministry of the Roman Catholic Archdiocese of Detroit.

Among the notable figures buried there are:

• Larry Aurie, hockey player for the Detroit Red Wings^[1]
• Vince Banonis, football player for the Detroit Lions^[2]
• Vincent M. Brennan, U.S. Representative from Michigan^[3]
• Anthony Giacalone, a Detroit Mafia Member & Suspect in the murder of Jimmy Hoffa
• William Bufalino, Mafia Lawyer and Legal Counsel to Jimmy Hoffa, rumored member of the Mafia
• Angelo Meli, a known member of the Detroit Mafia
• William Tocco, known member of the Detroit Mafia
• Walter Briggs Sr., owner of the Detroit Tigers^[4]
• Al Cicotte, baseball player for the Detroit Tigers^[5]
• Charles Coughlin, Roman Catholic priest and noted radio commentator during the 1930s and 1940s^[6]
• John Francis Dearden, Archbishop of Detroit, 1958–1980, created Cardinal in 1969^[7]
• John Dingell Sr., American politician

• Charlie Gehringer, Hall of Fame baseball player for the Detroit Tigers
• Walter Hagen, professional golfer, winner of eleven major championships
• Harry Heilmann, Hall of Fame baseball player for the Detroit Tigers and Cincinnati Reds
• Mike Ilitch, businessman who founded the pizza restaurant chain Little Caesars and was also later the principal owner of the Detroit Red Wings and the Detroit Tigers
• Viola Liuzzo, American civil rights activist and murder victim
• Edward Aloysius Mooney, Archbishop of Detroit, 1937–1958, created Cardinal in 1946
• Francis Joseph Navin, principal owner of the Detroit Tigers from 1908 to 1935
• Dick Radatz, Major League Baseball relief pitcher^[8]
• Jay Sebring, murder victim of the Manson Family
• Edmund Szoka, Archbishop of Detroit, 1981–1990, created Cardinal in 1988
• Vic Wertz, 4-time All-Star professional baseball player, he was the batter who hit the ball for Willie Mays' most famous catch