Hitotsubashi (一ツ橋) may refer to:

• Hitotsubashi, Chiyoda, a place in Chiyoda, Tokyo
• Hitotsubashi Group, a publishing keiretsu
• Hitotsubashi University
• Hitotsubashi-Tokugawa, a branch of the Tokugawa Clan
• Hitotsubashi Yoshinobu (Keiki), the last shōgun