DC3 or DC-3 may refer to:
Music
- DC3 (band), a defunct American rock band
- The DC3, a defunct Australian rock band
Transportation
- Datsun DC-3, a 1952 automobile
- Douglas DC-3, a 1930s aircraft
- North American DC-3, a cancelled space shuttle design
Other uses
- DC3 Music Group, a multi-media entertainment company
- Device Control Three, a control codes used in text by computer systems
- Department of Defense Cyber Crime Center (DC3), a United States defense organization
- Dodge City Community College, Kansas, U.S.