Novak Djokovic defeated Stanislas Wawrinka in the final, 4–6, 6–3, 6–3 to win the men's singles tennis title at the 2008 Italian Open.^[1][2]

Rafael Nadal was the three-time defending champion, but lost in the second round to Juan Carlos Ferrero.^[3][4] Notably, this marked the first of two instances that Nadal lost his opening match at a clay court tournament.

The top eight seeds receive a bye into the second round.

	Quarterfinals							Semifinals							Final
	1	Roger Federer	64	67
		Radek Štěpánek	7	7
									Radek Štěpánek	0	0r
								3	Novak Djokovic	6	1
	3	Novak Djokovic	6	1
		Nicolás Almagro	1	0r
															3	Novak Djokovic	4	6	6
																Stanislas Wawrinka	6	3	3
	6	Andy Roddick	6	4	7
	14	Tommy Robredo	3	6	64
								6	Andy Roddick	0r
									Stanislas Wawrinka	3
	8	James Blake	7	65	1
		Stanislas Wawrinka	65	7	6

	First round							Second round							Third round							Quarterfinals
								1	R Federer	6	6
		G Cañas	68	6	6				G Cañas	3	3
	WC	G Naso	7	3	2										1	R Federer	7	6
		P Starace	6	2	6											I Karlović	64	3
		M Čilić	4	6	4				P Starace	3	7	63
		I Karlović	7	6					I Karlović	6	65	7
	15	P-H Mathieu	64	2																		1	R Federer	64	67
	9	R Gasquet	4	1																			R Štěpánek	7	7
	Q	L Horna	6	6				Q	L Horna	6	7
		D Tursunov	4	2					J Acasuso	3	61
		J Acasuso	6	6											Q	L Horna	4	6	3
		J Nieminen	3	6	3											R Štěpánek	6	1	6
		R Štěpánek	6	3	6				R Štěpánek	4	6	6
								5	D Ferrer	6	2	1

	First round							Second round							Third round							Quarterfinals
								3	N Djokovic	6	6
		S Darcis	7	7					S Darcis	4	0
		I Ljubičić	5	65											3	N Djokovic	6	3	6
		H-t Lee	4	5												I Andreev	3	6	3
		I Andreev	6	7					I Andreev	4	6	6
	Q	P Cuevas	0	4				13	J Mónaco	6	1	4
	13	J Mónaco	6	6																		3	N Djokovic	6	1
	12	F González	3	7	7																		N Almagro	1	0r
		J Tipsarević	6	60	66			12	F González	6	6
	Q	E Korolev	1	6	6			Q	E Korolev	3	2
		R Söderling	6	3	4										12	F González
		N Almagro	6	6												N Almagro	w/o
	WC	F Cipolla	1	3					N Almagro	6	7
								7	D Nalbandian	4	5

	First round							Second round							Third round							Quarterfinals
								6	A Roddick	6	6
		M Llodra	5	6	62				M Fish	1	4
		M Fish	7	3	7										6	A Roddick	7	6
		S Bolelli	6	6												S Bolelli	65	3
	Q	O Patience	0	3					S Bolelli	6	6
		G Simon	6	4	7				G Simon	4	4
	10	J-W Tsonga	2	6	66																	6	A Roddick	6	4	7
	14	T Robredo	6	6																		14	T Robredo	3	6	64
		JI Chela	4	1				14	T Robredo	7	7
		N Mahut	65	6	7				N Mahut	5	65
	Q	T Fabbiano	7	4	5										14	T Robredo	4	6	7
	WC	M Ančić	6	6											4	N Davydenko	6	2	64
		F López	4	4				WC	M Ančić	2	2
								4	N Davydenko	6	6

	First round							Second round							Third round							Quarterfinals
								8	J Blake	7	3	6
		A Seppi	6	6					A Seppi	65	6	1
		F Santoro	4	2											8	J Blake	5	7	6
		F Volandri	66	6	2											F Verdasco	7	5	2
	Q	N Lapentti	7	2	6			Q	N Lapentti	2	7	2
		F Verdasco	6	6					F Verdasco	6	5	6
	11	C Moyá	3	4																		8	J Blake	7	65	1
	16	A Murray	5	6	1																		S Wawrinka	65	7	6
	Q	JM del Potro	7	4	0r			16	A Murray	2	65
	WC	M Safin	7	2	1				S Wawrinka	6	7
		S Wawrinka	65	6	6											S Wawrinka	6	6
		JC Ferrero	65	6	6											JC Ferrero	4	3
		N Kiefer	7	3	4				JC Ferrero	7	6
								2	R Nadal	5	1

	First round							Qualifying competition
	1	Gaël Monfils	6	6
	Alt	Manuel Sánchez	4	2
								1	Gaël Monfils	3	0r
								13	Olivier Patience	6	1
		Stefano Galvani	2	6	4
	13	Olivier Patience	6	4	6

	First round							Qualifying competition
	2	Jonas Björkman	6	3	77
	WC	Matteo Trevisan	4	6	65
								2	Jonas Björkman	66	2
								8	Evgeny Korolev	78	6
		Andrey Golubev	3	3
	8	Evgeny Korolev	6	6

	First round							Qualifying competition
	3	Victor Hănescu	4	0r
	WC	Thomas Fabbiano	6	3
								WC	Thomas Fabbiano	3	7	6
								9	Boris Pašanski	6	5	3
	WC	Andrea Arnaboldi	6	3	3
	9	Boris Pašanski	4	6	6

	First round							Qualifying competition
	4	Mischa Zverev	6	5	6
		Yuri Schukin	4	7	2
								4	Mischa Zverev	2	5
								12	Luis Horna	6	7
		Max Mirnyi	4	6	4
	12	Luis Horna	6	2	6

	First round							Qualifying competition
	5	Juan Martín del Potro	6	4	6
		Francesco Aldi	0	6	2
								5	Juan Martín del Potro	6	6
								11	Benjamin Becker	1	1
		Simone Vagnozzi	6	4	2
	11	Benjamin Becker	4	6	6

	First round							Qualifying competition
	6	Nicolás Lapentti	3	6	7
		Paolo Lorenzi	6	1	5
								6	Nicolás Lapentti	6	6
								14	Édouard Roger-Vasselin	2	0
		Adrián García	4	3
	14	Édouard Roger-Vasselin	6	6

	First round							Qualifying competition
	7	Arnaud Clément	4	6	6
		Leonardo Azzaro	6	2	3
								7	Arnaud Clément	3	3
								10	Pablo Cuevas	6	6
	WC	Matteo Marrai	3	6	1
	10	Pablo Cuevas	6	4	6

• Draw
• Qualifying draw
• ITF tournament profile