Yitzhak(pronunciation^ⓘ (יִצְחָק‎)) is a male first name, and is Hebrew for Isaac. Yitzhak may refer to:

• Yitzhak ha-Sangari, rabbi who converted the Khazars to Judaism
• Yitzhak Rabin (1922–1995), Israeli politician and Prime Minister
• Yitzhak Shamir (1915–2012), Israeli politician and Prime Minister
• Yitzhak Aharonovich (born 1950), Israeli politician
• Yitzhak Apeloig (born 1944), Israeli computational chemistry professor and President of the Technion
• Yitzhak Arad (1926–2021), Israeli historian
• Yitzhak Ben-Aharon (1906–2006), Israeli politician
• Yitzhak Ben-Zvi (1884–1963), Israeli politician and President
• Yitzhak Danziger (1916–1977), Israeli sculptor
• Yitzhak Hatuel (born 1962), Israeli Olympic foil fencer
• Yitzhak Hofi (1927–2014), Israeli general
• Yitzhak Laor (born 1948), Israeli poet
• Yitzhak Mastai (born 1966), Israeli professor of chemistry
• Yitzhak Y. Melamed (born 1968), Israeli-American philosophy professor
• Yitzhak Molcho (born 1945), Israeli lawyer
• Yitzhak Mordechai (born 1944), Israeli general and politician
• Yitzhak Navon (1921–2015), Israel politician and President
• Yitzhak "Vicky" Peretz (1953–2021), Israeli Olympic footballer
• Yitzhak Sadeh (1890–1952), Israeli general
• Yitzhak Schwartz, birth name of Irving Fields (1915–2016), American pianist and composer
• Yitzhak Tshuva (born 1948), Israeli businessman
• Yitzhak Yosef (born 1952), Israeli chief rabbi

• Yitzhak, fictional character in the musical and film Hedwig and the Angry Inch

• Itzhak