A quintuplet is one of five siblings from a multiple birth.

Quintuplet may also refer to:

• In music, a tuplet of five successive notes of equal duration
• The Quintuplet cluster, a star cluster near the Galactic Center
• Quintuplets, an American sitcom
• "Quintuplets 2000", an episode of the American television series South Park
• The Quintessential Quintuplets, an anime series centered around five sisters