Oxus may refer to :

• Oxus River, also called the Amu Darya, Amu or Amo River, a major river in Central Asia.
• Oxus valley (disambiguation)
• Oxus civilization, a bronze age civilization of central Asia
• Oxus (god), an Eastern Iranian god regarded as the personification of the Amu Darya
• Oxus Cobra, also known as the Caspian cobra, Central Asian cobra, or Russian cobra

• Oxus Treasure
• Transoxiana