Mike Bryan and Jack Sock won their second consecutive Grand Slam as a pair, defeating Łukasz Kubot and Marcelo Melo in the final, 6–3, 6–1.^[1] Mike Bryan won an all-time record 18th grand slam men's doubles title, and with a sixth US Open men's doubles title, he equals Richard Sears and Holcombe Ward.

Bryan retained the ATP number 1 doubles ranking at the conclusion of this tournament, after fellow contenders Oliver Marach and John Peers both lost in the early rounds.^[2] Sock reached a career-high ranking of no. 2 after this tournament.

Jean-Julien Rojer and Horia Tecău were the defending champions,^[3] but lost in the second round to Radu Albot and Malek Jaziri. Albot and Jaziri became the first Moldovan and Tunisian respectively to reach the semifinals at a Grand Slam.

Click on the seed number of a player to go to their draw section.

	Quarterfinals							Semifinals							Final
		Austin Krajicek Tennys Sandgren	4	2
	7	Łukasz Kubot Marcelo Melo	6	6
								7	Łukasz Kubot Marcelo Melo	77	3	6
								Alt	Radu Albot Malek Jaziri	63	6	3
	4	Jamie Murray Bruno Soares	5	4
	Alt	Radu Albot Malek Jaziri	7	6
															7	Łukasz Kubot Marcelo Melo	3	1
															3	Mike Bryan Jack Sock	6	6
		Máximo González Nicolás Jarry	4	63
	3	Mike Bryan Jack Sock	6	77
								3	Mike Bryan Jack Sock	6	61	6
								5	Juan Sebastián Cabal Robert Farah	2	77	4
	5	Juan Sebastián Cabal Robert Farah	6	6
	15	Rohan Bopanna Édouard Roger-Vasselin	3	4

	First round							Second round							Third round							Quarterfinals
	1	O Marach M Pavić	6	65	5
		L Mayer J Sousa	3	77	7				L Mayer J Sousa	3	3
		P Gojowczyk P Raja	62	4				PR	N Mektić J Melzer	6	6
	PR	N Mektić J Melzer	77	6											PR	N Mektić J Melzer	3	4
		J Erlich A-u-H Qureshi	3	4												A Krajicek T Sandgren	6	6
		A Krajicek T Sandgren	6	6					A Krajicek T Sandgren	6	77
		F Nielsen J Salisbury	4	2				13	J Peralta H Zeballos	4	64
	13	J Peralta H Zeballos	6	6																			A Krajicek T Sandgren	4	2
	9	P-H Herbert N Mahut	6	3	77																	7	Ł Kubot M Melo	6	6
		N Monroe J-P Smith	3	6	62			9	P-H Herbert N Mahut	7	6
		S Bolelli F Fognini	6	3	6				S Bolelli F Fognini	5	3
		K Krawietz M Marterer	4	6	3										9	P-H Herbert N Mahut	5	6	3
		D Sharan A Sitak	6	6											7	Ł Kubot M Melo	7	2	6
	WC	Ma Redlicki E Zhu	4	4					D Sharan A Sitak	3	6	3
	Alt	H Hach Verdugo A Siljeström	3	62				7	Ł Kubot M Melo	6	3	6
	7	Ł Kubot M Melo	6	77

	First round							Second round							Third round							Quarterfinals
	4	J Murray B Soares	6	6
		G Pella A Ramos Viñolas	2	3				4	J Murray B Soares	6	6
		M Daniell W Koolhof	6	710					M Daniell W Koolhof	3	4
		M Mirnyi P Oswald	3	68											4	J Murray B Soares	77	6
		P Petzschner T Pütz	6	6											14	R Haase M Middelkoop	64	4
		J Eysseric M Fucsovics	1	2					P Petzschner T Pütz	3	6	1
	WC	C Eubanks D Young	2	6	66			14	R Haase M Middelkoop	6	3	6
	14	R Haase M Middelkoop	6	4	78																	4	J Murray B Soares	5	4
	10	F López M López	4	6	6																	Alt	R Albot M Jaziri	7	6
	WC	P Kypson D Thomas	6	2	4			10	F López M López	2	6	3
	WC	B Klahn D Nestor	3	3				WC	C Harrison R Harrison	6	4	6
	WC	C Harrison R Harrison	6	6											WC	C Harrison R Harrison	2	6	65
	Alt	R Albot M Jaziri	77	77											Alt	R Albot M Jaziri	6	4	77
		K Skupski N Skupski	64	65				Alt	R Albot M Jaziri	3	710	6
		S Arends A Šančić	3	4				6	J-J Rojer H Tecău	6	68	2
	6	J-J Rojer H Tecău	6	6

	First round							Second round							Third round							Quarterfinals
	8	R Klaasen M Venus	6	6
		L Lacko J Millman	2	2				8	R Klaasen M Venus	3	65
		M González N Jarry	6	6					M González N Jarry	6	77
		D Marrero M Matkowski	3	4												M González N Jarry	6	6
	WC	E King N Pasha	4	4												R Jebavý A Molteni	3	4
		R Jebavý A Molteni	6	6					R Jebavý A Molteni	77	6
		M Berrettini A Seppi	77	1	6				M Berrettini A Seppi	63	4
	12	B McLachlan J-L Struff	65	6	4																		M González N Jarry	4	63
	16	D Inglot F Škugor	6	711																		3	M Bryan J Sock	6	77
		R Lindstedt R Ram	4	69				16	D Inglot F Škugor	65	6	6
		C Norrie D Schwartzman	6	4	1				D Lajović S Tsitsipas	77	3	4
		D Lajović S Tsitsipas	3	6	6										16	D Inglot F Škugor	2	4
	PR	M McDonald Y Nishioka	6	6											3	M Bryan J Sock	6	6
		M Bašić D Džumhur	3	2				PR	M McDonald Y Nishioka	1	5
		D Bracciali M Cecchinato	1	1				3	M Bryan J Sock	6	7
	3	M Bryan J Sock	6	6

	First round							Second round							Third round							Quarterfinals
	5	JS Cabal R Farah	6	6
	Alt	D Istomin J Nedunchezhiyan	3	2				5	JS Cabal R Farah	6	77
		M Demoliner S González	7	77					M Demoliner S González	4	64
		H Nys B Paire	5	62											5	JS Cabal R Farah	6	2	6
	Alt	R Galloway N Lammons	6	6											11	I Dodig M Granollers	2	6	3
	WC	K King R Opelka	2	2				Alt	R Galloway N Lammons	4	61
	Alt	R Arneodo L Bambridge	3	77	4			11	I Dodig M Granollers	6	77
	11	I Dodig M Granollers	6	64	6																	5	JS Cabal R Farah	6	6
	15	R Bopanna É Roger-Vasselin	4	6	6																	15	R Bopanna É Roger-Vasselin	3	4
		M Baghdatis M Zverev	6	3	4			15	R Bopanna É Roger-Vasselin	6	6
		F Krajinović V Troicki	3	2					M Ebden J Withrow	4	4
		M Ebden J Withrow	6	6											15	R Bopanna É Roger-Vasselin	78	4	6
		J Chardy F Martin	6	6												J Chardy F Martin	66	6	3
		J Cerretani L Paes	3	4					J Chardy F Martin	77	3	77
		M Arévalo MÁ Reyes-Varela	7	62	65			2	H Kontinen J Peers	64	6	63
	2	H Kontinen J Peers	5	77	77

• Main draw
• 2018 US Open – Men's draws and results at the International Tennis Federation