The 1966 Purdue Boilermakers football team represented Purdue University in the 1966 Big Ten Conference football season. The Boilermakers, led by future National Football League (NFL) quarterback Bob Griese, won the 1967 Rose Bowl. Griese led Purdue to a second-place finish in the Big Ten Conference and the school's first appearance in the Rose Bowl Game. The Boilermakers were the runner-up in the Big Ten behind Michigan State, but received the conference's Rose Bowl berth because of the Big Ten's "no-repeat" rule at the time. Griese was a two-time All-American at Purdue and was the runner-up to Steve Spurrier for the Heisman Trophy in 1966.

Date	Opponent	Rank	Site	TV	Result	Attendance
September 17	Ohio*	No. 8	Ross–Ade Stadium West Lafayette, IN		W 42–3	47,172
September 24	at No. 8 Notre Dame*	No. 7	Notre Dame Stadium Notre Dame, IN (rivalry)	ABC	L 14–26	59,075
October 1	SMU*		Ross–Ade Stadium West Lafayette, IN		W 35–23	46,116
October 8	Iowa		Ross–Ade Stadium West Lafayette, IN		W 35–0	52,715
October 15	at Michigan	No. 9	Michigan Stadium Ann Arbor, MI		W 22–21	79,642
October 22	at No. 2 Michigan State	No. 9	Spartan Stadium East Lansing, MI	ABC	L 20–41	78,014
October 29	Illinois		Ross–Ade Stadium West Lafayette, IN (rivalry)		W 25–21	61,643
November 5	at Wisconsin		Camp Randall Stadium Madison, WI		W 23–0	56,475
November 12	at Minnesota		Memorial Stadium Minneapolis, MN		W 16–0	49,085
November 19	Indiana	No. 10	Ross–Ade Stadium West Lafayette, IN (Old Oaken Bucket)		W 51–6	62,197
January 1	vs. USC*	No. 7	Rose Bowl Pasadena, CA (Rose Bowl)	NBC	W 14–13	101,438
*Non-conference game Homecoming Rankings from AP Poll released prior to the game

^[1]

• Purdue clinches Rose Bowl berth
• Bob Griese 11/21, 255 Yds, 3 TD, 1 FG, 6/7 XP
• Leroy Keyes Rush TD, Pass TD, INT
• Jim Beirne 2 TD Rec
• Biggest margin in rivalry since 1893^[2]

^[3]

• Bob Griese, Sammy Baugh Trophy^[4]
• Bob Griese, second in Heisman Trophy voting