William Wentworth may refer to:
- Ordered chronologically
- William Wentworth, 2nd Earl of Strafford (1626–1695), United Kingdom peer, 2nd Earl of Strafford
- William Wentworth, 2nd Earl of Strafford (1722–1791), United Kingdom peer, 2nd Earl of Strafford of a later creation
- William Wentworth (elder) (1616–1697), ancestor of most North American Wentworths
- William Wentworth (1790–1872), Australian statesman, explorer, barrister, newspaper publisher, politician and landowner
- William P. Wentworth (1839–1896), American architect
- Bill Wentworth (1907–2003), Australian politician, first federal Minister for Aboriginal Affairs
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