USS Carlisle (APA-69) was a Gilliam-class attack transport that served with the United States Navy from 1944 to 1946. She was sunk as a target ship during Operation Crossroads in July 1946.

Carlisle was named after a county in Kentucky. She was launched 30 July 1944 by Consolidated Steel at San Pedro, California, under a Maritime Commission contract; acquired by the Navy 28 November 1944 and commissioned the next day.

Carlisle cleared San Diego 23 January 1945, carrying sailors, Marines, and general cargo to Pearl Harbor. She returned to San Francisco 11 February, and after repairs, sailed to San Diego to load passengers and cargo for Pearl Harbor. Between 2 April and 5 June, she had duty training and transporting Marine units among the islands of the Hawaiian group.

Carlisle made three voyages to the west coast from Hawaii and Japan, and shorter passages among South Pacific islands, redeploying servicemen until 4 February 1946.

Carlisle was then assigned as a target vessel for Operation Crossroads, the atomic bomb tests at Bikini Atoll, and was sunk in one of those tests on 1 July 1946. Carlisle was decommissioned at Bikini Atoll and struck from the Navy Register, both dates unknown.

Carlisle received two Navy Occupation Service Medals for service during the occupation of Japan after World War II.

•  This article incorporates text from the public domain Dictionary of American Naval Fighting Ships. The entry can be found here.
• APA-69 Carlisle, Navsource Online.